node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACX72005.1 | ACX72006.1 | Metvu_0137 | Metvu_0138 | PFAM: cysteine-rich small domain; KEGG: mja:MJ0836 hypothetical protein. | Metal dependent phosphohydrolase; KEGG: mja:MJ0837 cmp-binding-factor 1 isolog; TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region. | 0.661 |
ACX72006.1 | ACX72005.1 | Metvu_0138 | Metvu_0137 | Metal dependent phosphohydrolase; KEGG: mja:MJ0837 cmp-binding-factor 1 isolog; TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region. | PFAM: cysteine-rich small domain; KEGG: mja:MJ0836 hypothetical protein. | 0.661 |
ACX72006.1 | dphB | Metvu_0138 | Metvu_1279 | Metal dependent phosphohydrolase; KEGG: mja:MJ0837 cmp-binding-factor 1 isolog; TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.493 |
ACX72006.1 | mptA | Metvu_0138 | Metvu_0037 | Metal dependent phosphohydrolase; KEGG: mja:MJ0837 cmp-binding-factor 1 isolog; TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region. | Protein of unknown function DUF198; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | 0.931 |
ACX72006.1 | mptD | Metvu_0138 | Metvu_0827 | Metal dependent phosphohydrolase; KEGG: mja:MJ0837 cmp-binding-factor 1 isolog; TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region. | Protein of unknown function DUF372; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family. | 0.678 |
ACX72006.1 | mptE | Metvu_0138 | Metvu_1362 | Metal dependent phosphohydrolase; KEGG: mja:MJ0837 cmp-binding-factor 1 isolog; TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region. | Protein of unknown function DUF115; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family. | 0.811 |
ACX72006.1 | purL | Metvu_0138 | Metvu_0685 | Metal dependent phosphohydrolase; KEGG: mja:MJ0837 cmp-binding-factor 1 isolog; TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region. | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] | 0.519 |
ACX72006.1 | purS | Metvu_0138 | Metvu_1676 | Metal dependent phosphohydrolase; KEGG: mja:MJ0837 cmp-binding-factor 1 isolog; TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region. | Phosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] | 0.438 |
ACX72006.1 | rad50 | Metvu_0138 | Metvu_1124 | Metal dependent phosphohydrolase; KEGG: mja:MJ0837 cmp-binding-factor 1 isolog; TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region. | SMC domain protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.451 |
ACX72006.1 | ribB | Metvu_0138 | Metvu_0493 | Metal dependent phosphohydrolase; KEGG: mja:MJ0837 cmp-binding-factor 1 isolog; TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | 0.819 |
ACX72006.1 | trpF | Metvu_0138 | Metvu_1734 | Metal dependent phosphohydrolase; KEGG: mja:MJ0837 cmp-binding-factor 1 isolog; TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region. | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: mja:MJ0451 phosphoribosylanthranilate isomerase (TrpF); Belongs to the TrpF family. | 0.556 |
dphB | ACX72006.1 | Metvu_1279 | Metvu_0138 | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | Metal dependent phosphohydrolase; KEGG: mja:MJ0837 cmp-binding-factor 1 isolog; TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region. | 0.493 |
mptA | ACX72006.1 | Metvu_0037 | Metvu_0138 | Protein of unknown function DUF198; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | Metal dependent phosphohydrolase; KEGG: mja:MJ0837 cmp-binding-factor 1 isolog; TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region. | 0.931 |
mptA | mptD | Metvu_0037 | Metvu_0827 | Protein of unknown function DUF198; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | Protein of unknown function DUF372; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family. | 0.577 |
mptA | mptE | Metvu_0037 | Metvu_1362 | Protein of unknown function DUF198; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | Protein of unknown function DUF115; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family. | 0.488 |
mptD | ACX72006.1 | Metvu_0827 | Metvu_0138 | Protein of unknown function DUF372; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family. | Metal dependent phosphohydrolase; KEGG: mja:MJ0837 cmp-binding-factor 1 isolog; TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region. | 0.678 |
mptD | mptA | Metvu_0827 | Metvu_0037 | Protein of unknown function DUF372; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family. | Protein of unknown function DUF198; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | 0.577 |
mptD | mptE | Metvu_0827 | Metvu_1362 | Protein of unknown function DUF372; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family. | Protein of unknown function DUF115; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family. | 0.993 |
mptE | ACX72006.1 | Metvu_1362 | Metvu_0138 | Protein of unknown function DUF115; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family. | Metal dependent phosphohydrolase; KEGG: mja:MJ0837 cmp-binding-factor 1 isolog; TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region. | 0.811 |
mptE | mptA | Metvu_1362 | Metvu_0037 | Protein of unknown function DUF115; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family. | Protein of unknown function DUF198; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | 0.488 |