Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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alaSalanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (895 aa)    
Predicted Functional Partners:
leuS
TIGRFAM: leucyl-tRNA synthetase; KEGG: mja:MJ0633 leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
 
 0.969
ileS
isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
 
 
 0.956
ACX71891.1
PFAM: WD40 repeat, subgroup; SMART: WD-40 repeat protein; KEGG: mba:Mbar_A3390 hypothetical protein.
  
 0.944
valS
valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
 
  
 0.929
ACX72228.1
GHMP kinase; KEGG: mfe:Mefer_0856 GHMP kinase.
  
    0.921
ACX72861.1
PFAM: Serine/threonine protein kinase-related; tyrosine protein kinase; TPR repeat-containing protein; Tetratricopeptide TPR_3; Tetratricopeptide TPR_2 repeat protein; SMART: serine/threonine protein kinase; tyrosine protein kinase; Tetratricopeptide repeat; KEGG: tga:TGAM_0974 serine/threonine protein kinase.
   
 0.879
thrS
TIGRFAM: threonyl-tRNA synthetase; PFAM: Threonyl-tRNA synthetase editing domain protein; tRNA synthetase class II (G H P and S); Anticodon-binding domain protein; KEGG: mja:MJ1197 threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family.
 
 
 0.875
htpX
PFAM: peptidase M48 Ste24p; KEGG: mfe:Mefer_0977 peptidase M48 Ste24p; Belongs to the peptidase M48B family.
  
  
 0.871
glyS
glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly).
  
 
 0.862
ACX73305.1
PFAM: aminotransferase class V; KEGG: mja:MJ0959 aspartate aminotransferase (AspC).
  
  
 0.860
Your Current Organism:
Methanocaldococcus vulcanius
NCBI taxonomy Id: 579137
Other names: M. vulcanius M7, Methanocaldococcus vulcanius M7, Methanocaldococcus vulcanius str. M7, Methanocaldococcus vulcanius strain M7
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