STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ACX72243.1Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (244 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
 0.999
ACX73301.1
TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: mfe:Mefer_0849 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family.
 
 0.997
ACX72401.1
Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mfe:Mefer_0258 porphobilinogen synthase; Belongs to the ALAD family.
 
 
 0.978
ACX73110.1
Precorrin-4 C11-methyltransferase; KEGG: mja:MJ1578 cobalamin biosynthesis precorrin-3 methylase (CbiF); TIGRFAM: precorrin-4 C11-methyltransferase; uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase.
   
 0.941
ACX73533.1
KEGG: mja:MJ0235 hypothetical protein.
  
    0.902
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.857
ACX72268.1
PFAM: TrkA-N domain protein; TrkA-C domain protein; KEGG: mja:MJ1105 trk system potassium uptake protein (TrkA).
  
    0.855
ACX72715.1
PFAM: amino acid-binding ACT domain protein; KEGG: mja:MJ1458 hypothetical protein.
  
    0.850
hemL
TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: mja:MJ0603 glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
 
  
 0.799
ACX72244.1
TIGRFAM: hydrogenase expression/formation protein HypD; PFAM: hydrogenase formation HypD protein; KEGG: mja:MJ0993 hydrogenase expression/formation protein (HypD).
     
 0.787
Your Current Organism:
Methanocaldococcus vulcanius
NCBI taxonomy Id: 579137
Other names: M. vulcanius M7, Methanocaldococcus vulcanius M7, Methanocaldococcus vulcanius str. M7, Methanocaldococcus vulcanius strain M7
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