STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ccaCCA-adding enzyme; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. (437 aa)    
Predicted Functional Partners:
ACX72627.1
PFAM: Protein of unknown function DUF530; KEGG: mja:MJ1110 hypothetical protein.
  
    0.878
endA
tRNA intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
 
   
 0.758
nac
alpha-NAC related protein; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family.
 
     0.716
ACX72748.1
2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family.
 
   
 0.713
dtdA
Protein of unknown function DUF516; D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
  
   
 0.688
ACX73399.1
PFAM: Protein of unknown function DUF655; KEGG: mja:MJ0038 hypothetical protein.
 
   
 0.670
dnaG
TOPRIM domain protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
 
     0.657
ACX73223.1
PFAM: Glycosyl transferase, family 4, conserved region; KEGG: mja:MJ1113 N-acetylglucosamine-1-phosphate transferase.
       0.648
rtcB
PFAM: protein of unknown function UPF0027; SMART: Hedgehog/intein hint domain protein; KEGG: mja:MJ0682 hypothetical protein; Belongs to the RtcB family.
      
 0.632
ACX72280.1
KEGG: mja:MJ1399 hypothetical protein; Belongs to the UPF0200 family.
 
     0.629
Your Current Organism:
Methanocaldococcus vulcanius
NCBI taxonomy Id: 579137
Other names: M. vulcanius M7, Methanocaldococcus vulcanius M7, Methanocaldococcus vulcanius str. M7, Methanocaldococcus vulcanius strain M7
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