STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ACX72745.1PFAM: protein of unknown function DUF87; HerA-ATP synthase, barrel domain; KEGG: mja:MJ1565 hypothetical protein. (510 aa)    
Predicted Functional Partners:
ACX72674.1
PFAM: NurA domain; KEGG: mja:MJ1262 hypothetical protein.
   
 
 0.865
rad50
SMC domain protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily.
 
   
 0.837
mre11
Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family.
 
   
 0.816
ACX72744.1
PFAM: Protein of unknown function DUF54; KEGG: mfe:Mefer_0550 protein of unknown function DUF54; Belongs to the UPF0201 family.
       0.768
infB
Translation initiation factor aIF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.
   
   0.657
hisB
PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mfe:Mefer_1092 imidazoleglycerol-phosphate dehydratase.
       0.574
ACX72963.1
TIGRFAM: dihydropteroate synthase-related protein; PFAM: dihydropteroate synthase DHPS; KEGG: mfe:Mefer_0347 dihydropteroate synthase-related protein.
 
     0.511
Your Current Organism:
Methanocaldococcus vulcanius
NCBI taxonomy Id: 579137
Other names: M. vulcanius M7, Methanocaldococcus vulcanius M7, Methanocaldococcus vulcanius str. M7, Methanocaldococcus vulcanius strain M7
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.