| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACX72704.1 | ACX72879.1 | Metvu_0846 | Metvu_1021 | PFAM: THUMP domain protein; KEGG: mja:MJ0421 hypothetical protein. | KEGG: mja:MJ1629 hypothetical protein; Belongs to the UPF0282 family. | 0.548 |
| ACX72704.1 | ACX73284.1 | Metvu_0846 | Metvu_1431 | PFAM: THUMP domain protein; KEGG: mja:MJ0421 hypothetical protein. | PFAM: Circadian clock protein KaiC central region; KaiA binding; KEGG: mja:MJ1359 hypothetical protein; Belongs to the UPF0273 family. | 0.493 |
| ACX72704.1 | rgy | Metvu_0846 | Metvu_1264 | PFAM: THUMP domain protein; KEGG: mja:MJ0421 hypothetical protein. | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. | 0.670 |
| ACX72879.1 | ACX72704.1 | Metvu_1021 | Metvu_0846 | KEGG: mja:MJ1629 hypothetical protein; Belongs to the UPF0282 family. | PFAM: THUMP domain protein; KEGG: mja:MJ0421 hypothetical protein. | 0.548 |
| ACX72879.1 | rgy | Metvu_1021 | Metvu_1264 | KEGG: mja:MJ1629 hypothetical protein; Belongs to the UPF0282 family. | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. | 0.484 |
| ACX72996.1 | rgy | Metvu_1138 | Metvu_1264 | PFAM: zinc finger SWIM domain protein; KEGG: mfe:Mefer_0891 zinc finger SWIM domain protein. | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. | 0.481 |
| ACX73117.1 | rgy | Metvu_1263 | Metvu_1264 | TIGRFAM: RNA methyltransferase, TrmH family, group 1; PFAM: tRNA/rRNA methyltransferase (SpoU); KEGG: mja:MJ1476 hypothetical protein. | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. | 0.491 |
| ACX73134.1 | rgy | Metvu_1281 | Metvu_1264 | Metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. | 0.565 |
| ACX73284.1 | ACX72704.1 | Metvu_1431 | Metvu_0846 | PFAM: Circadian clock protein KaiC central region; KaiA binding; KEGG: mja:MJ1359 hypothetical protein; Belongs to the UPF0273 family. | PFAM: THUMP domain protein; KEGG: mja:MJ0421 hypothetical protein. | 0.493 |
| ACX73284.1 | rgy | Metvu_1431 | Metvu_1264 | PFAM: Circadian clock protein KaiC central region; KaiA binding; KEGG: mja:MJ1359 hypothetical protein; Belongs to the UPF0273 family. | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. | 0.641 |
| ACX73321.1 | albA | Metvu_1468 | Metvu_1603 | TIGRFAM: 3-hydroxy-3-methylglutaryl Coenzyme A reductase; PFAM: hydroxymethylglutaryl-coenzyme A reductase; KEGG: mja:MJ0705 3-hydroxy-3-methylglutaryl coenzyme A reductase; Belongs to the HMG-CoA reductase family. | DNA-binding protein Alba; Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes; Belongs to the histone-like Alba family. | 0.538 |
| ACX73321.1 | rgy | Metvu_1468 | Metvu_1264 | TIGRFAM: 3-hydroxy-3-methylglutaryl Coenzyme A reductase; PFAM: hydroxymethylglutaryl-coenzyme A reductase; KEGG: mja:MJ0705 3-hydroxy-3-methylglutaryl coenzyme A reductase; Belongs to the HMG-CoA reductase family. | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. | 0.680 |
| ACX73321.1 | sucD | Metvu_1468 | Metvu_0393 | TIGRFAM: 3-hydroxy-3-methylglutaryl Coenzyme A reductase; PFAM: hydroxymethylglutaryl-coenzyme A reductase; KEGG: mja:MJ0705 3-hydroxy-3-methylglutaryl coenzyme A reductase; Belongs to the HMG-CoA reductase family. | succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.454 |
| albA | ACX73321.1 | Metvu_1603 | Metvu_1468 | DNA-binding protein Alba; Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes; Belongs to the histone-like Alba family. | TIGRFAM: 3-hydroxy-3-methylglutaryl Coenzyme A reductase; PFAM: hydroxymethylglutaryl-coenzyme A reductase; KEGG: mja:MJ0705 3-hydroxy-3-methylglutaryl coenzyme A reductase; Belongs to the HMG-CoA reductase family. | 0.538 |
| albA | rgy | Metvu_1603 | Metvu_1264 | DNA-binding protein Alba; Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes; Belongs to the histone-like Alba family. | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. | 0.597 |
| fbp | rgy | Metvu_0943 | Metvu_1264 | Protein of unknown function DUF100; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. | 0.555 |
| rgy | ACX72704.1 | Metvu_1264 | Metvu_0846 | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. | PFAM: THUMP domain protein; KEGG: mja:MJ0421 hypothetical protein. | 0.670 |
| rgy | ACX72879.1 | Metvu_1264 | Metvu_1021 | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. | KEGG: mja:MJ1629 hypothetical protein; Belongs to the UPF0282 family. | 0.484 |
| rgy | ACX72996.1 | Metvu_1264 | Metvu_1138 | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. | PFAM: zinc finger SWIM domain protein; KEGG: mfe:Mefer_0891 zinc finger SWIM domain protein. | 0.481 |
| rgy | ACX73117.1 | Metvu_1264 | Metvu_1263 | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. | TIGRFAM: RNA methyltransferase, TrmH family, group 1; PFAM: tRNA/rRNA methyltransferase (SpoU); KEGG: mja:MJ1476 hypothetical protein. | 0.491 |
