| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACX72069.1 | ACX72070.1 | Metvu_0202 | Metvu_0203 | TIGRFAM: small GTP-binding protein; PFAM: TGS domain protein; GTP-binding protein HSR1-related; KEGG: mja:MJ1326 GTP1/Obg family GTP-binding protein. | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.863 |
| ACX72069.1 | dphB | Metvu_0202 | Metvu_1279 | TIGRFAM: small GTP-binding protein; PFAM: TGS domain protein; GTP-binding protein HSR1-related; KEGG: mja:MJ1326 GTP1/Obg family GTP-binding protein. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.684 |
| ACX72069.1 | fen | Metvu_0202 | Metvu_0646 | TIGRFAM: small GTP-binding protein; PFAM: TGS domain protein; GTP-binding protein HSR1-related; KEGG: mja:MJ1326 GTP1/Obg family GTP-binding protein. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.429 |
| ACX72069.1 | fusA | Metvu_0202 | Metvu_1528 | TIGRFAM: small GTP-binding protein; PFAM: TGS domain protein; GTP-binding protein HSR1-related; KEGG: mja:MJ1326 GTP1/Obg family GTP-binding protein. | Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] | 0.557 |
| ACX72069.1 | rpl15e | Metvu_0202 | Metvu_0558 | TIGRFAM: small GTP-binding protein; PFAM: TGS domain protein; GTP-binding protein HSR1-related; KEGG: mja:MJ1326 GTP1/Obg family GTP-binding protein. | PFAM: Ribosomal protein L15e; KEGG: mja:MJ0983 50S ribosomal protein L15e; Belongs to the eukaryotic ribosomal protein eL15 family. | 0.822 |
| ACX72069.1 | rpl37ae | Metvu_0202 | Metvu_1593 | TIGRFAM: small GTP-binding protein; PFAM: TGS domain protein; GTP-binding protein HSR1-related; KEGG: mja:MJ1326 GTP1/Obg family GTP-binding protein. | Ribosomal protein L37a; Binds to the 23S rRNA. | 0.706 |
| ACX72070.1 | ACX72069.1 | Metvu_0203 | Metvu_0202 | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | TIGRFAM: small GTP-binding protein; PFAM: TGS domain protein; GTP-binding protein HSR1-related; KEGG: mja:MJ1326 GTP1/Obg family GTP-binding protein. | 0.863 |
| ACX72070.1 | ACX72608.1 | Metvu_0203 | Metvu_0750 | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | TIGRFAM: ATP binding protein; PFAM: protein of unknown function DUF71 ATP-binding region; KEGG: mja:MJ0570 hypothetical protein. | 0.738 |
| ACX72070.1 | ACX73236.1 | Metvu_0203 | Metvu_1383 | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | PFAM: protein of unknown function Met10; KEGG: mja:MJ0883 hypothetical protein. | 0.461 |
| ACX72070.1 | dphB | Metvu_0203 | Metvu_1279 | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.952 |
| ACX72070.1 | fusA | Metvu_0203 | Metvu_1528 | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] | 0.982 |
| ACX72070.1 | rpl37ae | Metvu_0203 | Metvu_1593 | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Ribosomal protein L37a; Binds to the 23S rRNA. | 0.738 |
| ACX72161.1 | dphB | Metvu_0294 | Metvu_1279 | PFAM: Protein of unknown function DUF357; KEGG: mfe:Mefer_0888 protein of unknown function DUF357. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.594 |
| ACX72608.1 | ACX72070.1 | Metvu_0750 | Metvu_0203 | TIGRFAM: ATP binding protein; PFAM: protein of unknown function DUF71 ATP-binding region; KEGG: mja:MJ0570 hypothetical protein. | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.738 |
| ACX72608.1 | dphB | Metvu_0750 | Metvu_1279 | TIGRFAM: ATP binding protein; PFAM: protein of unknown function DUF71 ATP-binding region; KEGG: mja:MJ0570 hypothetical protein. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.857 |
| ACX72608.1 | fen | Metvu_0750 | Metvu_0646 | TIGRFAM: ATP binding protein; PFAM: protein of unknown function DUF71 ATP-binding region; KEGG: mja:MJ0570 hypothetical protein. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.477 |
| ACX72608.1 | fusA | Metvu_0750 | Metvu_1528 | TIGRFAM: ATP binding protein; PFAM: protein of unknown function DUF71 ATP-binding region; KEGG: mja:MJ0570 hypothetical protein. | Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] | 0.950 |
| ACX73133.1 | dphB | Metvu_1280 | Metvu_1279 | PFAM: sodium/hydrogen exchanger; KEGG: mja:MJ1275 Na(+)/H(+) antiporter (NapA). | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.612 |
| ACX73236.1 | ACX72070.1 | Metvu_1383 | Metvu_0203 | PFAM: protein of unknown function Met10; KEGG: mja:MJ0883 hypothetical protein. | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.461 |
| ACX73236.1 | dphB | Metvu_1383 | Metvu_1279 | PFAM: protein of unknown function Met10; KEGG: mja:MJ0883 hypothetical protein. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.796 |
