STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACX73144.1PFAM: helicase domain protein; SNF2-related protein; type III restriction protein res subunit; SMART: DEAD-like helicase; helicase domain protein; KEGG: tna:CTN_1587 helicase domain protein. (994 aa)    
Predicted Functional Partners:
ACX73142.1
PFAM: protein of unknown function DUF499; KEGG: pfu:PF0566 hypothetical protein.
 
     0.932
fen
Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...]
 
 0.916
ACX72249.1
Transcription termination factor Tfs; KEGG: mja:MJ1148 transcription-associated protein ('TFIIS'); TIGRFAM: transcription factor S; PFAM: DNA-directed RNA polymerase, M/15 kDa subunit; Transcription factor TFIIS; SMART: Transcription factor TFIIS; DNA-directed RNA polymerase, M/15 kDa subunit; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
   
 0.900
ACX73487.1
PFAM: RNA polymerase insert; RNA polymerase dimerisation; SMART: RNA polymerase RpoA/D/Rpb3-type; KEGG: mja:MJ0192 DNA-directed RNA polymerase, subunit D (RpoD).
   
 0.900
ACX72861.1
PFAM: Serine/threonine protein kinase-related; tyrosine protein kinase; TPR repeat-containing protein; Tetratricopeptide TPR_3; Tetratricopeptide TPR_2 repeat protein; SMART: serine/threonine protein kinase; tyrosine protein kinase; Tetratricopeptide repeat; KEGG: tga:TGAM_0974 serine/threonine protein kinase.
 
 0.898
ACX73482.1
PFAM: RNA polymerase Rpb6; KEGG: mja:MJ0197 DNA-directed RNA polymerase, subunit K (RpoK).
   
 0.898
pcn
Proliferating cell nuclear antigen PcnA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
  
 0.891
rpoP
RNA polymerase Rbp10; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family.
    
 0.871
rpoN
RNA polymerase, N/8 Kd subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family.
    
 0.870
ACX73143.1
KEGG: pab:PAB0590 hypothetical protein.
       0.869
Your Current Organism:
Methanocaldococcus vulcanius
NCBI taxonomy Id: 579137
Other names: M. vulcanius M7, Methanocaldococcus vulcanius M7, Methanocaldococcus vulcanius str. M7, Methanocaldococcus vulcanius strain M7
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.