STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ACX73226.1PFAM: Xylose isomerase domain protein TIM barrel; SMART: AP endonuclease family 2; KEGG: mja:MJ0133 hypothetical protein. (268 aa)    
Predicted Functional Partners:
nth
DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
  
 
 0.814
ACX73121.1
PFAM: Beta propeller domain; KEGG: mja:MJ1554 hypothetical protein.
  
 
 0.796
ACX71928.1
TIGRFAM: histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; KEGG: mfe:Mefer_0530 histidinol-phosphate phosphatase family protein.
  
 
 0.755
ACX71955.1
KEGG: mja:MJ0885 DNA polymerase B1; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B; Hedgehog/intein hint domain protein.
   
 
 0.703
fen
Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...]
  
 
 0.638
ACX71954.1
PFAM: AMMECR1 domain protein; KEGG: mja:MJ0810 hypothetical protein.
       0.594
ACX72166.1
PFAM: Protein of unknown function DUF373; KEGG: mja:MJ1032 hypothetical protein.
       0.594
ACX72033.1
PFAM: protein of unknown function DUF77; KEGG: mja:MJ1052 hypothetical protein.
       0.589
ACX72865.1
PFAM: DEAD/DEAH box helicase domain protein; ERCC4 domain protein; helix-hairpin-helix motif; helicase domain protein; type III restriction protein res subunit; SMART: DEAD-like helicase; helicase domain protein; Helix-hairpin-helix DNA-binding class 1; KEGG: mja:MJ1505 Hef nuclease.
    
 
 0.585
ACX72255.1
TIGRFAM: 6-phospho 3-hexuloisomerase; PFAM: sugar isomerase (SIS); KEGG: mja:MJ1247 hypothetical protein.
       0.578
Your Current Organism:
Methanocaldococcus vulcanius
NCBI taxonomy Id: 579137
Other names: M. vulcanius M7, Methanocaldococcus vulcanius M7, Methanocaldococcus vulcanius str. M7, Methanocaldococcus vulcanius strain M7
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