STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ACX73236.1PFAM: protein of unknown function Met10; KEGG: mja:MJ0883 hypothetical protein. (336 aa)    
Predicted Functional Partners:
rfcL
AAA ATPase central domain protein; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily.
 
     0.834
ACX73234.1
PFAM: methyltransferase small; putative RNA methylase; KEGG: mja:MJ0882 hypothetical protein.
  
    0.806
dphB
Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
 
  
 0.796
tfb
Transcription factor TFIIB cyclin-releated protein; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
 
     0.694
taw1
Wyosine base formation domain protein; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
 
  
 0.690
ACX72823.1
KEGG: mja:MJ1136 hypothetical protein; TIGRFAM: histone acetyltransferase, ELP3 family; PFAM: Radical SAM domain protein; GCN5-related N-acetyltransferase; SMART: Elongator protein 3/MiaB/NifB.
 
  
 0.687
taw3
Protein of unknown function DUF207; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family.
 
  
 0.678
hel308
DEAD/DEAH box helicase domain protein; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
 
     0.661
ACX72037.1
PFAM: tRNA methyltransferase complex GCD14 subunit; KEGG: mja:MJ0134 L-isoaspartyl protein carboxyl methyltransferase isolog (PimT).
  
  
 0.609
ACX72496.1
PFAM: ABC transporter related; 4Fe-4S ferredoxin iron-sulfur binding domain protein; metal-binding domain in RNase L inhibitor, RLI; SMART: AAA ATPase; KEGG: mja:MJ0719 putative ATPase RIL.
 
    0.607
Your Current Organism:
Methanocaldococcus vulcanius
NCBI taxonomy Id: 579137
Other names: M. vulcanius M7, Methanocaldococcus vulcanius M7, Methanocaldococcus vulcanius str. M7, Methanocaldococcus vulcanius strain M7
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.