node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACX71955.1 | ACX73061.1 | Metvu_0086 | Metvu_1203 | KEGG: mja:MJ0885 DNA polymerase B1; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B; Hedgehog/intein hint domain protein. | PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: mja:MJ1159 replication factor A. | 0.941 |
ACX71955.1 | ACX73121.1 | Metvu_0086 | Metvu_1267 | KEGG: mja:MJ0885 DNA polymerase B1; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B; Hedgehog/intein hint domain protein. | PFAM: Beta propeller domain; KEGG: mja:MJ1554 hypothetical protein. | 0.876 |
ACX71955.1 | fen | Metvu_0086 | Metvu_0646 | KEGG: mja:MJ0885 DNA polymerase B1; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B; Hedgehog/intein hint domain protein. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.987 |
ACX71955.1 | mre11 | Metvu_0086 | Metvu_1125 | KEGG: mja:MJ0885 DNA polymerase B1; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B; Hedgehog/intein hint domain protein. | Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.677 |
ACX71955.1 | pcn | Metvu_0086 | Metvu_1567 | KEGG: mja:MJ0885 DNA polymerase B1; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B; Hedgehog/intein hint domain protein. | Proliferating cell nuclear antigen PcnA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.994 |
ACX71955.1 | rad50 | Metvu_0086 | Metvu_1124 | KEGG: mja:MJ0885 DNA polymerase B1; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B; Hedgehog/intein hint domain protein. | SMC domain protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.829 |
ACX71955.1 | radA | Metvu_0086 | Metvu_1398 | KEGG: mja:MJ0885 DNA polymerase B1; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B; Hedgehog/intein hint domain protein. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.890 |
ACX71955.1 | topA | Metvu_0086 | Metvu_0725 | KEGG: mja:MJ0885 DNA polymerase B1; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B; Hedgehog/intein hint domain protein. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.616 |
ACX73061.1 | ACX71955.1 | Metvu_1203 | Metvu_0086 | PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: mja:MJ1159 replication factor A. | KEGG: mja:MJ0885 DNA polymerase B1; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B; Hedgehog/intein hint domain protein. | 0.941 |
ACX73061.1 | ACX73121.1 | Metvu_1203 | Metvu_1267 | PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: mja:MJ1159 replication factor A. | PFAM: Beta propeller domain; KEGG: mja:MJ1554 hypothetical protein. | 0.961 |
ACX73061.1 | fen | Metvu_1203 | Metvu_0646 | PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: mja:MJ1159 replication factor A. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.757 |
ACX73061.1 | mre11 | Metvu_1203 | Metvu_1125 | PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: mja:MJ1159 replication factor A. | Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.961 |
ACX73061.1 | pcn | Metvu_1203 | Metvu_1567 | PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: mja:MJ1159 replication factor A. | Proliferating cell nuclear antigen PcnA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.980 |
ACX73061.1 | rad50 | Metvu_1203 | Metvu_1124 | PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: mja:MJ1159 replication factor A. | SMC domain protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.780 |
ACX73061.1 | radA | Metvu_1203 | Metvu_1398 | PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: mja:MJ1159 replication factor A. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.928 |
ACX73061.1 | topA | Metvu_1203 | Metvu_0725 | PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: mja:MJ1159 replication factor A. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.967 |
ACX73121.1 | ACX71955.1 | Metvu_1267 | Metvu_0086 | PFAM: Beta propeller domain; KEGG: mja:MJ1554 hypothetical protein. | KEGG: mja:MJ0885 DNA polymerase B1; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B; Hedgehog/intein hint domain protein. | 0.876 |
ACX73121.1 | ACX73061.1 | Metvu_1267 | Metvu_1203 | PFAM: Beta propeller domain; KEGG: mja:MJ1554 hypothetical protein. | PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: mja:MJ1159 replication factor A. | 0.961 |
ACX73121.1 | fen | Metvu_1267 | Metvu_0646 | PFAM: Beta propeller domain; KEGG: mja:MJ1554 hypothetical protein. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.966 |
ACX73121.1 | mre11 | Metvu_1267 | Metvu_1125 | PFAM: Beta propeller domain; KEGG: mja:MJ1554 hypothetical protein. | Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.530 |