| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACX72056.1 | ACX73134.1 | Metvu_0189 | Metvu_1281 | Cytidyltransferase-related domain protein; KEGG: mja:MJ1030 phosphopantetheine adenylyltransferase; TIGRFAM: cytidyltransferase-related domain protein; PFAM: cytidylyltransferase. | Metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. | 0.555 |
| ACX72056.1 | ACX73326.1 | Metvu_0189 | Metvu_1473 | Cytidyltransferase-related domain protein; KEGG: mja:MJ1030 phosphopantetheine adenylyltransferase; TIGRFAM: cytidyltransferase-related domain protein; PFAM: cytidylyltransferase. | Protein of unknown function DUF359; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | 0.936 |
| ACX73134.1 | ACX72056.1 | Metvu_1281 | Metvu_0189 | Metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. | Cytidyltransferase-related domain protein; KEGG: mja:MJ1030 phosphopantetheine adenylyltransferase; TIGRFAM: cytidyltransferase-related domain protein; PFAM: cytidylyltransferase. | 0.555 |
| ACX73134.1 | ACX73324.1 | Metvu_1281 | Metvu_1471 | Metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. | KEGG: mja:MJ0397 DNA-directed RNA polymerase subunit E'; TIGRFAM: DNA-directed RNA polymerase; PFAM: RNA polymerase Rpb7 domain protein; RNA binding S1 domain protein. | 0.891 |
| ACX73134.1 | ACX73326.1 | Metvu_1281 | Metvu_1473 | Metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. | Protein of unknown function DUF359; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | 0.875 |
| ACX73134.1 | ACX73470.1 | Metvu_1281 | Metvu_1617 | Metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.929 |
| ACX73134.1 | rps24e | Metvu_1281 | Metvu_1474 | Metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. | PFAM: Ribosomal protein S24e; KEGG: mja:MJ0394 30S ribosomal protein S24e; Belongs to the eukaryotic ribosomal protein eS24 family. | 0.949 |
| ACX73134.1 | rps27ae | Metvu_1281 | Metvu_1475 | Metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. | PFAM: Ribosomal protein S27a; KEGG: mja:MJ0393 30S ribosomal protein S27ae; Belongs to the eukaryotic ribosomal protein eS31 family. | 0.875 |
| ACX73134.1 | rps6e | Metvu_1281 | Metvu_0814 | Metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. | PFAM: Ribosomal protein S6e; KEGG: mja:MJ1260 30S ribosomal protein S6e; Belongs to the eukaryotic ribosomal protein eS6 family. | 0.881 |
| ACX73134.1 | spt4 | Metvu_1281 | Metvu_1472 | Metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. | DNA-directed RNA polymerase subunit E, RpoE2; Stimulates transcription elongation; Belongs to the archaeal Spt4 family. | 0.892 |
| ACX73324.1 | ACX73134.1 | Metvu_1471 | Metvu_1281 | KEGG: mja:MJ0397 DNA-directed RNA polymerase subunit E'; TIGRFAM: DNA-directed RNA polymerase; PFAM: RNA polymerase Rpb7 domain protein; RNA binding S1 domain protein. | Metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. | 0.891 |
| ACX73324.1 | ACX73326.1 | Metvu_1471 | Metvu_1473 | KEGG: mja:MJ0397 DNA-directed RNA polymerase subunit E'; TIGRFAM: DNA-directed RNA polymerase; PFAM: RNA polymerase Rpb7 domain protein; RNA binding S1 domain protein. | Protein of unknown function DUF359; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | 0.987 |
| ACX73324.1 | ACX73470.1 | Metvu_1471 | Metvu_1617 | KEGG: mja:MJ0397 DNA-directed RNA polymerase subunit E'; TIGRFAM: DNA-directed RNA polymerase; PFAM: RNA polymerase Rpb7 domain protein; RNA binding S1 domain protein. | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.663 |
| ACX73324.1 | rps24e | Metvu_1471 | Metvu_1474 | KEGG: mja:MJ0397 DNA-directed RNA polymerase subunit E'; TIGRFAM: DNA-directed RNA polymerase; PFAM: RNA polymerase Rpb7 domain protein; RNA binding S1 domain protein. | PFAM: Ribosomal protein S24e; KEGG: mja:MJ0394 30S ribosomal protein S24e; Belongs to the eukaryotic ribosomal protein eS24 family. | 0.941 |
| ACX73324.1 | rps27ae | Metvu_1471 | Metvu_1475 | KEGG: mja:MJ0397 DNA-directed RNA polymerase subunit E'; TIGRFAM: DNA-directed RNA polymerase; PFAM: RNA polymerase Rpb7 domain protein; RNA binding S1 domain protein. | PFAM: Ribosomal protein S27a; KEGG: mja:MJ0393 30S ribosomal protein S27ae; Belongs to the eukaryotic ribosomal protein eS31 family. | 0.921 |
| ACX73324.1 | rps6e | Metvu_1471 | Metvu_0814 | KEGG: mja:MJ0397 DNA-directed RNA polymerase subunit E'; TIGRFAM: DNA-directed RNA polymerase; PFAM: RNA polymerase Rpb7 domain protein; RNA binding S1 domain protein. | PFAM: Ribosomal protein S6e; KEGG: mja:MJ1260 30S ribosomal protein S6e; Belongs to the eukaryotic ribosomal protein eS6 family. | 0.817 |
| ACX73324.1 | spt4 | Metvu_1471 | Metvu_1472 | KEGG: mja:MJ0397 DNA-directed RNA polymerase subunit E'; TIGRFAM: DNA-directed RNA polymerase; PFAM: RNA polymerase Rpb7 domain protein; RNA binding S1 domain protein. | DNA-directed RNA polymerase subunit E, RpoE2; Stimulates transcription elongation; Belongs to the archaeal Spt4 family. | 0.998 |
| ACX73326.1 | ACX72056.1 | Metvu_1473 | Metvu_0189 | Protein of unknown function DUF359; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | Cytidyltransferase-related domain protein; KEGG: mja:MJ1030 phosphopantetheine adenylyltransferase; TIGRFAM: cytidyltransferase-related domain protein; PFAM: cytidylyltransferase. | 0.936 |
| ACX73326.1 | ACX73134.1 | Metvu_1473 | Metvu_1281 | Protein of unknown function DUF359; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | Metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. | 0.875 |
| ACX73326.1 | ACX73324.1 | Metvu_1473 | Metvu_1471 | Protein of unknown function DUF359; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | KEGG: mja:MJ0397 DNA-directed RNA polymerase subunit E'; TIGRFAM: DNA-directed RNA polymerase; PFAM: RNA polymerase Rpb7 domain protein; RNA binding S1 domain protein. | 0.987 |
