STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACX73429.1TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; KEGG: mja:MJ0503 trans-homoaconitate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (406 aa)    
Predicted Functional Partners:
ACX72610.1
KEGG: mja:MJ1596 3-isopropylmalate dehydrogenase 2 (leuB2); TIGRFAM: isopropylmalate/isohomocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase.
 
 0.974
leuC-2
Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 
 0.971
hacB
3-isopropylmalate dehydratase, small subunit; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD [...]
  
 
 0.957
leuD
3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
  
 
 0.957
ACX72409.1
PFAM: Thiolase; KEGG: mja:MJ1549 acetyl-CoA acetyltransferase.
  
 
 0.944
ACX72552.1
PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: mja:MJ0276 2-oxoglutarate ferredoxin oxidoreductase subunit alpha.
  
 
 0.934
ACX73017.1
PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: mja:MJ0267 pyruvate ferredoxin oxidoreductase, subunit alpha (PorA).
  
 
 0.918
ACX73018.1
PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: mfe:Mefer_0883 thiamine pyrophosphate protein domain protein TPP-binding.
  
 
 0.917
ACX73093.1
PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: mja:MJ0537 2-oxoglutarate ferredoxin oxidoreductase subunit beta.
  
 
 0.917
ACX73015.1
TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase; KEGG: mja:MJ0269 pyruvate ferredoxin oxidoreductase subunit gamma.
    
 0.913
Your Current Organism:
Methanocaldococcus vulcanius
NCBI taxonomy Id: 579137
Other names: M. vulcanius M7, Methanocaldococcus vulcanius M7, Methanocaldococcus vulcanius str. M7, Methanocaldococcus vulcanius strain M7
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