node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACX72149.1 | thi4 | Metvu_0282 | Metvu_1585 | PFAM: Radical SAM domain protein; cobalamin B12-binding domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: mja:MJ0865 hypothetical protein. | Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.465 |
ACX73134.1 | thi4 | Metvu_1281 | Metvu_1585 | Metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. | Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.678 |
ACX73134.1 | topA | Metvu_1281 | Metvu_0725 | Metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.543 |
ACX73437.1 | thi4 | Metvu_1584 | Metvu_1585 | KEGG: mja:MJ0696 hypothetical protein. | Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.532 |
ACX73439.1 | ACX73440.1 | Metvu_1586 | Metvu_1587 | DNA adenine methylase; KEGG: mja:MJ0598 modification methylase, type II R/M system 2; TIGRFAM: DNA adenine methylase; PFAM: D12 class N6 adenine-specific DNA methyltransferase. | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: mja:MJ0597 hypothetical protein. | 0.774 |
ACX73439.1 | ACX73441.1 | Metvu_1586 | Metvu_1588 | DNA adenine methylase; KEGG: mja:MJ0598 modification methylase, type II R/M system 2; TIGRFAM: DNA adenine methylase; PFAM: D12 class N6 adenine-specific DNA methyltransferase. | KEGG: mfe:Mefer_1383 hypothetical protein. | 0.733 |
ACX73439.1 | thi4 | Metvu_1586 | Metvu_1585 | DNA adenine methylase; KEGG: mja:MJ0598 modification methylase, type II R/M system 2; TIGRFAM: DNA adenine methylase; PFAM: D12 class N6 adenine-specific DNA methyltransferase. | Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.487 |
ACX73440.1 | ACX73439.1 | Metvu_1587 | Metvu_1586 | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: mja:MJ0597 hypothetical protein. | DNA adenine methylase; KEGG: mja:MJ0598 modification methylase, type II R/M system 2; TIGRFAM: DNA adenine methylase; PFAM: D12 class N6 adenine-specific DNA methyltransferase. | 0.774 |
ACX73440.1 | ACX73441.1 | Metvu_1587 | Metvu_1588 | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: mja:MJ0597 hypothetical protein. | KEGG: mfe:Mefer_1383 hypothetical protein. | 0.975 |
ACX73440.1 | thi4 | Metvu_1587 | Metvu_1585 | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: mja:MJ0597 hypothetical protein. | Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.915 |
ACX73440.1 | thiC | Metvu_1587 | Metvu_0639 | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: mja:MJ0597 hypothetical protein. | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | 0.427 |
ACX73441.1 | ACX73439.1 | Metvu_1588 | Metvu_1586 | KEGG: mfe:Mefer_1383 hypothetical protein. | DNA adenine methylase; KEGG: mja:MJ0598 modification methylase, type II R/M system 2; TIGRFAM: DNA adenine methylase; PFAM: D12 class N6 adenine-specific DNA methyltransferase. | 0.733 |
ACX73441.1 | ACX73440.1 | Metvu_1588 | Metvu_1587 | KEGG: mfe:Mefer_1383 hypothetical protein. | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: mja:MJ0597 hypothetical protein. | 0.975 |
ACX73441.1 | thi4 | Metvu_1588 | Metvu_1585 | KEGG: mfe:Mefer_1383 hypothetical protein. | Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.904 |
ACX73534.1 | thi4 | Metvu_1681 | Metvu_1585 | PFAM: Phosphomethylpyrimidine kinase; Phosphomethylpyrimidine kinase type-1; KEGG: mja:MJ0236 hypothetical protein. | Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.881 |
ACX73534.1 | thiC | Metvu_1681 | Metvu_0639 | PFAM: Phosphomethylpyrimidine kinase; Phosphomethylpyrimidine kinase type-1; KEGG: mja:MJ0236 hypothetical protein. | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | 0.997 |
thi4 | ACX72149.1 | Metvu_1585 | Metvu_0282 | Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | PFAM: Radical SAM domain protein; cobalamin B12-binding domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: mja:MJ0865 hypothetical protein. | 0.465 |
thi4 | ACX73134.1 | Metvu_1585 | Metvu_1281 | Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | Metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. | 0.678 |
thi4 | ACX73437.1 | Metvu_1585 | Metvu_1584 | Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | KEGG: mja:MJ0696 hypothetical protein. | 0.532 |
thi4 | ACX73439.1 | Metvu_1585 | Metvu_1586 | Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | DNA adenine methylase; KEGG: mja:MJ0598 modification methylase, type II R/M system 2; TIGRFAM: DNA adenine methylase; PFAM: D12 class N6 adenine-specific DNA methyltransferase. | 0.487 |