node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS85456.1 | ACS86464.1 | Dd703_1659 | Dd703_2687 | PFAM: FAD linked oxidase domain protein; KEGG: eca:ECA1856 putative FAD-binding oxidase. | Sulfur relay protein, TusE/DsrC/DsvC family; Part of a sulfur-relay system. | 0.432 |
ACS85456.1 | thiI | Dd703_1659 | Dd703_2891 | PFAM: FAD linked oxidase domain protein; KEGG: eca:ECA1856 putative FAD-binding oxidase. | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.534 |
ACS85570.1 | ACS86464.1 | Dd703_1774 | Dd703_2687 | KEGG: eca:ECA2034 respiratory nitrate reductase 1 gamma chain; TIGRFAM: respiratory nitrate reductase, gamma subunit; PFAM: Nitrate reductase gamma subunit. | Sulfur relay protein, TusE/DsrC/DsvC family; Part of a sulfur-relay system. | 0.402 |
ACS86179.1 | ACS86464.1 | Dd703_2397 | Dd703_2687 | PFAM: Glycosyl transferase, family 3-like; KEGG: eca:ECA2772 hypothetical protein. | Sulfur relay protein, TusE/DsrC/DsvC family; Part of a sulfur-relay system. | 0.504 |
ACS86179.1 | tusB | Dd703_2397 | Dd703_0397 | PFAM: Glycosyl transferase, family 3-like; KEGG: eca:ECA2772 hypothetical protein. | Sulfur relay protein TusB/DsrH; Part of a sulfur-relay system required for 2-thiolation of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. | 0.505 |
ACS86463.1 | ACS86464.1 | Dd703_2686 | Dd703_2687 | PFAM: protein of unknown function UPF0005; KEGG: eca:ECA1763 hypothetical protein; Belongs to the BI1 family. | Sulfur relay protein, TusE/DsrC/DsvC family; Part of a sulfur-relay system. | 0.574 |
ACS86464.1 | ACS85456.1 | Dd703_2687 | Dd703_1659 | Sulfur relay protein, TusE/DsrC/DsvC family; Part of a sulfur-relay system. | PFAM: FAD linked oxidase domain protein; KEGG: eca:ECA1856 putative FAD-binding oxidase. | 0.432 |
ACS86464.1 | ACS85570.1 | Dd703_2687 | Dd703_1774 | Sulfur relay protein, TusE/DsrC/DsvC family; Part of a sulfur-relay system. | KEGG: eca:ECA2034 respiratory nitrate reductase 1 gamma chain; TIGRFAM: respiratory nitrate reductase, gamma subunit; PFAM: Nitrate reductase gamma subunit. | 0.402 |
ACS86464.1 | ACS86179.1 | Dd703_2687 | Dd703_2397 | Sulfur relay protein, TusE/DsrC/DsvC family; Part of a sulfur-relay system. | PFAM: Glycosyl transferase, family 3-like; KEGG: eca:ECA2772 hypothetical protein. | 0.504 |
ACS86464.1 | ACS86463.1 | Dd703_2687 | Dd703_2686 | Sulfur relay protein, TusE/DsrC/DsvC family; Part of a sulfur-relay system. | PFAM: protein of unknown function UPF0005; KEGG: eca:ECA1763 hypothetical protein; Belongs to the BI1 family. | 0.574 |
ACS86464.1 | mnmA | Dd703_2687 | Dd703_2063 | Sulfur relay protein, TusE/DsrC/DsvC family; Part of a sulfur-relay system. | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs; Belongs to the MnmA/TRMU family. | 0.935 |
ACS86464.1 | thiI | Dd703_2687 | Dd703_2891 | Sulfur relay protein, TusE/DsrC/DsvC family; Part of a sulfur-relay system. | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.405 |
ACS86464.1 | tusA | Dd703_2687 | Dd703_3882 | Sulfur relay protein, TusE/DsrC/DsvC family; Part of a sulfur-relay system. | SirA family protein; Sulfur carrier protein involved in sulfur trafficking in the cell. Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA. Interacts with IscS and stimulates its cysteine desulfurase activity. Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation. Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin. | 0.400 |
ACS86464.1 | tusB | Dd703_2687 | Dd703_0397 | Sulfur relay protein, TusE/DsrC/DsvC family; Part of a sulfur-relay system. | Sulfur relay protein TusB/DsrH; Part of a sulfur-relay system required for 2-thiolation of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. | 0.876 |
ACS86464.1 | tusC | Dd703_2687 | Dd703_0396 | Sulfur relay protein, TusE/DsrC/DsvC family; Part of a sulfur-relay system. | Sulfur relay protein TusC/DsrF; Part of a sulfur-relay system required for 2-thiolation of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. | 0.811 |
ACS86464.1 | tusD | Dd703_2687 | Dd703_0395 | Sulfur relay protein, TusE/DsrC/DsvC family; Part of a sulfur-relay system. | Sulfur relay protein TusD/DsrE; Part of a sulfur-relay system required for 2-thiolation of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE. | 0.985 |
mnmA | ACS86464.1 | Dd703_2063 | Dd703_2687 | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs; Belongs to the MnmA/TRMU family. | Sulfur relay protein, TusE/DsrC/DsvC family; Part of a sulfur-relay system. | 0.935 |
mnmA | thiI | Dd703_2063 | Dd703_2891 | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs; Belongs to the MnmA/TRMU family. | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.536 |
mnmA | tusA | Dd703_2063 | Dd703_3882 | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs; Belongs to the MnmA/TRMU family. | SirA family protein; Sulfur carrier protein involved in sulfur trafficking in the cell. Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA. Interacts with IscS and stimulates its cysteine desulfurase activity. Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation. Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin. | 0.402 |
thiI | ACS85456.1 | Dd703_2891 | Dd703_1659 | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | PFAM: FAD linked oxidase domain protein; KEGG: eca:ECA1856 putative FAD-binding oxidase. | 0.534 |