STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiIUnannotated protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (482 aa)    
Predicted Functional Partners:
iscS
Unannotated protein; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
  
 0.987
rsmB
Unannotated protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
  
    0.881
rsmF
Unannotated protein; Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA.
   
    0.866
thiG
Unannotated protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
  
 
 0.857
moeB
Unannotated protein.
    
 0.851
thiF_1
Unannotated protein.
    
 0.851
GCA_001266615_01594
Unannotated protein.
  
 0.842
GCA_001266615_01664
Unannotated protein.
  
 0.842
GCA_001266615_01945
Unannotated protein.
  
 0.842
gloB
Unannotated protein; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid.
  
 0.842
Your Current Organism:
Kluyvera cryocrescens
NCBI taxonomy Id: 580
Other names: ATCC 33435, CCUG 18767, CDC 2065-78, CIP 82.96, DSM 4588, Escherichia citrophila, JCM 7580, K. cryocrescens, Kluyvera citrophila, LMG 7859, LMG:7859, NBRC 102467, strain 12993
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.