Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Tthe_0010KEGG: tpd:Teth39_0241 FMN-binding domain-containing protein; PFAM: FMN-binding domain protein; SMART: FMN-binding domain protein. (150 aa)    
Predicted Functional Partners:
Tthe_1068
PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; TQO small subunit DoxD; KEGG: tte:TTE2486 NADH dehydrogenase, FAD-containing subunit.
 
    0.779
Tthe_1069
KEGG: amt:Amet_4332 heptaprenyl diphosphate synthase component I; manually curated; PFAM: Heptaprenyl diphosphate synthase component I.
 
     0.760
Tthe_0701
ApbE family lipoprotein; Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
 
   
 0.742
Tthe_0702
PFAM: protein of unknown function DUF1312; KEGG: tpd:Teth39_2118 hypothetical protein.
 
 
   0.628
Tthe_0341
PFAM: UbiA prenyltransferase; KEGG: cth:Cthe_3041 1,4-dihydroxy-2-naphthoate octaprenyltransferase.
 
   
 0.598
gyrA
DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
       0.517
gyrB
DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
       0.498
Tthe_1070
PFAM: Polyprenyl synthetase; KEGG: tex:Teth514_0672 polyprenyl synthetase; Belongs to the FPP/GGPP synthase family.
 
     0.489
Tthe_2248
PFAM: FMN-binding domain protein; KEGG: cce:Ccel_1394 FMN-binding domain protein.
  
     0.471
Your Current Organism:
Thermoanaerobacterium thermosaccharolyticum
NCBI taxonomy Id: 580327
Other names: T. thermosaccharolyticum DSM 571, Thermoanaerobacterium thermosaccharolyticum DSM 571, Thermoanaerobacterium thermosaccharolyticum str. DSM 571, Thermoanaerobacterium thermosaccharolyticum strain DSM 571
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