node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tthe_1379 | Tthe_2345 | Tthe_1379 | Tthe_2345 | KEGG: tpd:Teth39_1183 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Adenylosuccinate lyase-like; fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 5'-Nucleotidase domain protein; KEGG: tpd:Teth39_1938 5'-nucleotidase, 2',3'-cyclic-nucleotide 2'-phosphodiesterase; PFAM: 5'-Nucleotidase domain protein; SH3 type 3 domain protein; metallophosphoesterase; SMART: SH3 domain protein; Capsule synthesis protein, CapA. | 0.920 |
Tthe_1379 | apt | Tthe_1379 | Tthe_1551 | KEGG: tpd:Teth39_1183 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Adenylosuccinate lyase-like; fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.943 |
Tthe_1379 | cinA | Tthe_1379 | Tthe_1392 | KEGG: tpd:Teth39_1183 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Adenylosuccinate lyase-like; fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Competence/damage-inducible protein CinA; KEGG: tpd:Teth39_1192 competence damage-inducible protein A; TIGRFAM: competence/damage-inducible protein CinA; PFAM: CinA domain protein; molybdopterin binding domain; Belongs to the CinA family. | 0.500 |
Tthe_1379 | guaA | Tthe_1379 | Tthe_2115 | KEGG: tpd:Teth39_1183 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Adenylosuccinate lyase-like; fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.883 |
Tthe_1379 | guaB | Tthe_1379 | Tthe_2116 | KEGG: tpd:Teth39_1183 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Adenylosuccinate lyase-like; fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.871 |
Tthe_1379 | pyrF | Tthe_1379 | Tthe_1542 | KEGG: tpd:Teth39_1183 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Adenylosuccinate lyase-like; fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | TIGRFAM: orotidine 5'-phosphate decarboxylase; KEGG: tex:Teth514_1816 orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.424 |
Tthe_2037 | Tthe_2077 | Tthe_2037 | Tthe_2077 | SMART: AAA ATPase; KEGG: tpd:Teth39_0715 phosphoribulokinase/uridine kinase. | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.549 |
Tthe_2037 | Tthe_2345 | Tthe_2037 | Tthe_2345 | SMART: AAA ATPase; KEGG: tpd:Teth39_0715 phosphoribulokinase/uridine kinase. | 5'-Nucleotidase domain protein; KEGG: tpd:Teth39_1938 5'-nucleotidase, 2',3'-cyclic-nucleotide 2'-phosphodiesterase; PFAM: 5'-Nucleotidase domain protein; SH3 type 3 domain protein; metallophosphoesterase; SMART: SH3 domain protein; Capsule synthesis protein, CapA. | 0.918 |
Tthe_2037 | apt | Tthe_2037 | Tthe_1551 | SMART: AAA ATPase; KEGG: tpd:Teth39_0715 phosphoribulokinase/uridine kinase. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.402 |
Tthe_2037 | guaA | Tthe_2037 | Tthe_2115 | SMART: AAA ATPase; KEGG: tpd:Teth39_0715 phosphoribulokinase/uridine kinase. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.816 |
Tthe_2037 | guaB | Tthe_2037 | Tthe_2116 | SMART: AAA ATPase; KEGG: tpd:Teth39_0715 phosphoribulokinase/uridine kinase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.700 |
Tthe_2037 | pyrF | Tthe_2037 | Tthe_1542 | SMART: AAA ATPase; KEGG: tpd:Teth39_0715 phosphoribulokinase/uridine kinase. | TIGRFAM: orotidine 5'-phosphate decarboxylase; KEGG: tex:Teth514_1816 orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.922 |
Tthe_2037 | tdk | Tthe_2037 | Tthe_2537 | SMART: AAA ATPase; KEGG: tpd:Teth39_0715 phosphoribulokinase/uridine kinase. | KEGG: tpd:Teth39_2112 thymidine kinase; PFAM: thymidine kinase. | 0.490 |
Tthe_2037 | tmk | Tthe_2037 | Tthe_0077 | SMART: AAA ATPase; KEGG: tpd:Teth39_0715 phosphoribulokinase/uridine kinase. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.552 |
Tthe_2077 | Tthe_2037 | Tthe_2077 | Tthe_2037 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | SMART: AAA ATPase; KEGG: tpd:Teth39_0715 phosphoribulokinase/uridine kinase. | 0.549 |
Tthe_2077 | Tthe_2345 | Tthe_2077 | Tthe_2345 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 5'-Nucleotidase domain protein; KEGG: tpd:Teth39_1938 5'-nucleotidase, 2',3'-cyclic-nucleotide 2'-phosphodiesterase; PFAM: 5'-Nucleotidase domain protein; SH3 type 3 domain protein; metallophosphoesterase; SMART: SH3 domain protein; Capsule synthesis protein, CapA. | 0.913 |
Tthe_2077 | guaA | Tthe_2077 | Tthe_2115 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.974 |
Tthe_2077 | guaB | Tthe_2077 | Tthe_2116 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.926 |
Tthe_2345 | Tthe_1379 | Tthe_2345 | Tthe_1379 | 5'-Nucleotidase domain protein; KEGG: tpd:Teth39_1938 5'-nucleotidase, 2',3'-cyclic-nucleotide 2'-phosphodiesterase; PFAM: 5'-Nucleotidase domain protein; SH3 type 3 domain protein; metallophosphoesterase; SMART: SH3 domain protein; Capsule synthesis protein, CapA. | KEGG: tpd:Teth39_1183 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Adenylosuccinate lyase-like; fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.920 |
Tthe_2345 | Tthe_2037 | Tthe_2345 | Tthe_2037 | 5'-Nucleotidase domain protein; KEGG: tpd:Teth39_1938 5'-nucleotidase, 2',3'-cyclic-nucleotide 2'-phosphodiesterase; PFAM: 5'-Nucleotidase domain protein; SH3 type 3 domain protein; metallophosphoesterase; SMART: SH3 domain protein; Capsule synthesis protein, CapA. | SMART: AAA ATPase; KEGG: tpd:Teth39_0715 phosphoribulokinase/uridine kinase. | 0.918 |