Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Slit_0066KEGG: dar:Daro_0054 ammonium transporter; TIGRFAM: ammonium transporter; PFAM: ammonium transporter. (500 aa)    
Predicted Functional Partners:
Slit_0065
PFAM: nitrogen regulatory protein P-II; KEGG: dar:Daro_0053 nitrogen regulatory protein P-II; Belongs to the P(II) protein family.
 
 0.997
Slit_1653
PFAM: nitrogen regulatory protein P-II; KEGG: tmz:Tmz1t_1760 nitrogen regulatory protein P-II; Belongs to the P(II) protein family.
 
 0.990
Slit_0064
PFAM: conserved hypothetical protein; KEGG: dar:Daro_0052 hypothetical protein.
 
    0.706
Slit_0115
KEGG: mei:Msip34_2803 glutamate synthase (ferredoxin); PFAM: glutamate synthase; ferredoxin-dependent glutamate synthase; glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein.
 
  
 0.697
glnE
(Glutamate--ammonia-ligase) adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tra [...]
     
 0.658
Slit_1708
Sulfate transporter; KEGG: tmz:Tmz1t_1634 sulphate transporter; TIGRFAM: sulfate transporter; PFAM: sulphate transporter; Sulfate transporter/antisigma-factor antagonist STAS.
    
 
 0.653
Slit_2925
KEGG: mei:Msip34_2494 signal transduction histidine kinase, nitrogen specific, NtrB; PFAM: ATP-binding region ATPase domain protein; PAS fold-4 domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS domain containing protein.
 
 
 0.614
Slit_0067
KEGG: lch:Lcho_4374 hypothetical protein.
       0.550
mutL
DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
      
 0.530
Slit_1850
TIGRFAM: acetyl-CoA acetyltransferase; KEGG: neu:NE1527 acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
      
 0.528
Your Current Organism:
Sideroxydans lithotrophicus
NCBI taxonomy Id: 580332
Other names: S. lithotrophicus ES-1, Sideroxydans lithotrophicus ES-1, Sideroxydans lithotrophicus str. ES-1, Sideroxydans lithotrophicus strain ES-1, iron-oxidizing lithotroph ES-1
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