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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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Slit_0105Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (575 aa)    
Predicted Functional Partners:
Slit_0104
Phosphotransferase system, phosphocarrier protein HPr; KEGG: mfa:Mfla_0147 HPrNtr; TIGRFAM: phosphocarrier, HPr family; PFAM: phosphoryl transfer system HPr.
 
 0.999
Slit_0103
PFAM: PTS system fructose subfamily IIA component; KEGG: mmb:Mmol_2160 PTS system fructose subfamily IIA component.
 
   
 0.935
hprK
HPr kinase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
 
   
 0.854
Slit_0434
Putative PTS IIA-like nitrogen-regulatory protein PtsN; PFAM: phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2; KEGG: neu:NE0060 phosphotransferase system mannitol/fructose-specific IIA domain-containing protein.
 
  
 0.848
Slit_0100
KEGG: tbd:Tbd_2408 glutamate--cysteine ligase GshA; TIGRFAM: glutamate/cysteine ligase; PFAM: glutamate--cysteine ligase GshA.
       0.793
Slit_0101
ApbE family lipoprotein; Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein. Belongs to the ApbE family.
       0.789
Slit_0102
Hypothetical protein; KEGG: solute carrier family 37 member 2 (glycerol-3-phosphate transporter.
       0.773
Slit_0450
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))., Phosphate acetyltransferase; KEGG: azo:azo3211 malic enzyme; PFAM: malic protein NAD-binding; malic protein domain protein; phosphate acetyl/butaryl transferase.
  
  
 0.561
pgk
KEGG: mei:Msip34_0485 phosphoglycerate kinase; PFAM: phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.
   
  
 0.507
Slit_2458
PFAM: Carbohydrate kinase, FGGY-like; KEGG: fal:FRAAL4566 glycerol kinase.
 
   
 0.457
Your Current Organism:
Sideroxydans lithotrophicus
NCBI taxonomy Id: 580332
Other names: S. lithotrophicus ES-1, Sideroxydans lithotrophicus ES-1, Sideroxydans lithotrophicus str. ES-1, Sideroxydans lithotrophicus strain ES-1, iron-oxidizing lithotroph ES-1
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