Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Slit_0138KEGG: har:HEAR0170 putative rod shape-determining protein MreD; TIGRFAM: rod shape-determining protein MreD; PFAM: Rod shape-determining protein MreD. (172 aa)    
Predicted Functional Partners:
Slit_0137
Rod shape-determining protein MreC; Involved in formation and maintenance of cell shape.
 
 
 0.991
Slit_0136
KEGG: nmu:Nmul_A0320 rod shape-determining protein MreB; TIGRFAM: cell shape determining protein, MreB/Mrl family; PFAM: cell shape determining protein MreB/Mrl.
 
  
 0.911
mrdB
Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily.
 
  
 0.813
mrdA
Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily.
 
  
 0.763
Slit_2849
TIGRFAM: DNA polymerase III, delta subunit; KEGG: har:HEAR2663 DNA polymerase III subunit delta; PFAM: DNA polymerase III delta.
  
     0.756
ftsB
Septum formation initiator; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
  
   
 0.734
Slit_0011
Conserved hypothetical protein; Manually curated; KEGG: app:CAP2UW1_0048 hypothetical protein.
  
     0.717
Slit_2683
Protein of unknown function DUF710; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.
  
   
 0.717
ftsQ
Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.
  
  
 0.613
Slit_0439
PFAM: protein of unknown function DUF1239; KEGG: mfa:Mfla_0139 hypothetical protein.
  
     0.610
Your Current Organism:
Sideroxydans lithotrophicus
NCBI taxonomy Id: 580332
Other names: S. lithotrophicus ES-1, Sideroxydans lithotrophicus ES-1, Sideroxydans lithotrophicus str. ES-1, Sideroxydans lithotrophicus strain ES-1, iron-oxidizing lithotroph ES-1
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