node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |

Slit_0037 | Slit_0268 | Slit_0037 | Slit_0268 | Porphobilinogen synthase | Uroporphyrinogen III synthase HEM4 | 0.936 |

Slit_0037 | cysG | Slit_0037 | Slit_1672 | Porphobilinogen synthase | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | 0.938 |

Slit_0037 | hemA | Slit_0037 | Slit_0255 | Porphobilinogen synthase | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) | 0.957 |

Slit_0037 | hemC | Slit_0037 | Slit_0267 | Porphobilinogen synthase | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps | 0.997 |

Slit_0037 | hemE | Slit_0037 | Slit_0117 | Porphobilinogen synthase | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III | 0.947 |

Slit_0037 | hemL | Slit_0037 | Slit_0039 | Porphobilinogen synthase | Glutamate-1-semialdehyde-2,1-aminomutase | 0.997 |

Slit_0268 | Slit_0037 | Slit_0268 | Slit_0037 | Uroporphyrinogen III synthase HEM4 | Porphobilinogen synthase | 0.936 |

Slit_0268 | cysG | Slit_0268 | Slit_1672 | Uroporphyrinogen III synthase HEM4 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | 0.998 |

Slit_0268 | hemA | Slit_0268 | Slit_0255 | Uroporphyrinogen III synthase HEM4 | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) | 0.913 |

Slit_0268 | hemC | Slit_0268 | Slit_0267 | Uroporphyrinogen III synthase HEM4 | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps | 0.999 |

Slit_0268 | hemE | Slit_0268 | Slit_0117 | Uroporphyrinogen III synthase HEM4 | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III | 0.947 |

Slit_0268 | hemL | Slit_0268 | Slit_0039 | Uroporphyrinogen III synthase HEM4 | Glutamate-1-semialdehyde-2,1-aminomutase | 0.870 |

cysG | Slit_0037 | Slit_1672 | Slit_0037 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | Porphobilinogen synthase | 0.938 |

cysG | Slit_0268 | Slit_1672 | Slit_0268 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | Uroporphyrinogen III synthase HEM4 | 0.998 |

cysG | hemA | Slit_1672 | Slit_0255 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) | 0.904 |

cysG | hemC | Slit_1672 | Slit_0267 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps | 0.991 |

cysG | hemE | Slit_1672 | Slit_0117 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III | 0.950 |

cysG | hemL | Slit_1672 | Slit_0039 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | Glutamate-1-semialdehyde-2,1-aminomutase | 0.911 |

gltX | hemA | Slit_1539 | Slit_0255 | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction- glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) | 0.938 |

gltX | hemC | Slit_1539 | Slit_0267 | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction- glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps | 0.501 |