Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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Score
ubiX3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (199 aa)    
Predicted Functional Partners:
ubiD
UbiD family decarboxylase; Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
 
 0.994
ubiA
4-hydroxybenzoate polyprenyl transferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
 
  
 0.966
Slit_0581
PFAM: Sterol-binding domain protein; KEGG: app:CAP2UW1_0991 hypothetical protein.
    
  0.910
Slit_0582
PFAM: peptidase U32; KEGG: dar:Daro_0108 peptidase U32.
    
  0.910
Slit_0290
KEGG: nmu:Nmul_A2444 ubiquinone biosynthesis hydroxylase family protein; TIGRFAM: Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; PFAM: monooxygenase FAD-binding.
     
 0.906
Slit_0583
PFAM: peptidase U32; KEGG: app:CAP2UW1_0989 peptidase U32.
  
 
  0.903
Slit_1084
PFAM: NUDIX hydrolase; KEGG: tbd:Tbd_0232 hypothetical protein.
     
  0.900
Slit_0430
KEGG: app:CAP2UW1_4050 heptaprenyl diphosphate synthase component I; manually curated; PFAM: Heptaprenyl diphosphate synthase component I.
       0.793
Slit_0432
Conserved hypothetical protein; Displays ATPase and GTPase activities.
       0.625
Slit_0431
PFAM: protein of unknown function DUF1312; KEGG: tmz:Tmz1t_0772 hypothetical protein.
       0.624
Your Current Organism:
Sideroxydans lithotrophicus
NCBI taxonomy Id: 580332
Other names: S. lithotrophicus ES-1, Sideroxydans lithotrophicus ES-1, Sideroxydans lithotrophicus str. ES-1, Sideroxydans lithotrophicus strain ES-1, iron-oxidizing lithotroph ES-1
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