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hisH protein (Sideroxydans lithotrophicus) - STRING interaction network
"hisH" - Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit in Sideroxydans lithotrophicus
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (239 aa)    
Predicted Functional Partners:
hisF
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (252 aa)
  0.999
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (253 aa)
 
 
  0.999
hisB
Imidazoleglycerol-phosphate dehydratase (195 aa)
 
 
  0.999
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (432 aa)
 
   
  0.987
Slit_0624
Histidinol-phosphate aminotransferase (364 aa)
 
   
  0.987
hisI
phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP (129 aa)
 
   
  0.981
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N’-(5’-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (212 aa)
 
   
  0.971
hisE
phosphoribosyl-ATP diphosphatase (105 aa)
 
   
  0.960
Slit_2064
Histidinol-phosphate aminotransferase (373 aa)
 
   
  0.923
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (520 aa)
   
 
  0.916
Your Current Organism:
Sideroxydans lithotrophicus
NCBI taxonomy Id: 580332
Other names: S. lithotrophicus, S. lithotrophicus ES-1, Siderooxidans, Siderooxidans lithoautotrophicus, Sideroxydans, Sideroxydans lithotrophicus, Sideroxydans lithotrophicus ES-1, Sideroxydans lithotrophicus str. ES-1, Sideroxydans lithotrophicus strain ES-1, iron-oxidizing lithotroph ES-1
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