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glyA protein (Sideroxydans lithotrophicus) - STRING interaction network
"glyA" - Glycine hydroxymethyltransferase in Sideroxydans lithotrophicus
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (415 aa)    
Predicted Functional Partners:
gcvT
Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine (361 aa)
 
  0.996
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (949 aa)
   
 
  0.993
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (520 aa)
   
  0.989
folD
Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (284 aa)
   
  0.987
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (129 aa)
   
 
  0.976
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate (212 aa)
 
 
  0.960
Slit_0652
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5’-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5’-phosphate (363 aa)
         
  0.958
Slit_2239
Phosphoserine phosphatase SerB (278 aa)
   
  0.955
Slit_0060
Methionine synthase (1239 aa)
     
 
  0.950
thyA
Thymidylate synthase; Provides the sole de novo source of dTMP for DNA biosynthesis (264 aa)
   
 
  0.949
Your Current Organism:
Sideroxydans lithotrophicus
NCBI taxonomy Id: 580332
Other names: S. lithotrophicus, S. lithotrophicus ES-1, Siderooxidans, Siderooxidans lithoautotrophicus, Sideroxydans, Sideroxydans lithotrophicus, Sideroxydans lithotrophicus ES-1, Sideroxydans lithotrophicus str. ES-1, Sideroxydans lithotrophicus strain ES-1, iron-oxidizing lithotroph ES-1
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