Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Slit_1012Histidine kinase; KEGG: rpi:Rpic_0576 integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein. (447 aa)    
Predicted Functional Partners:
Slit_1013
KEGG: rpi:Rpic_0575 two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver; transcriptional regulator domain protein.
 
 0.969
Slit_1160
KEGG: mgm:Mmc1_3164 multi-sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; response regulator receiver; Hpt domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; response regulator receiver; Hpt domain protein.
  
 
 0.926
Slit_2492
Two component transcriptional regulator, winged helix family; KEGG: dar:Daro_0429 response regulator receiver:transcriptional regulatory protein, C-terminal; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver; transcriptional regulator domain protein.
 
 0.845
Slit_2507
KEGG: nmu:Nmul_A0515 dihydrolipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: pyridine nucleotide-disulphide oxidoreductase dimerisation region; biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase.
    
 0.792
Slit_1289
KEGG: tgr:Tgr7_0082 Hpt sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; response regulator receiver; histidine kinase A domain protein; Hpt domain protein; SMART: ATP-binding region ATPase domain protein; response regulator receiver; histidine kinase A domain protein; Hpt domain protein.
 
 
0.766
Slit_2389
Two component transcriptional regulator, winged helix family; KEGG: dar:Daro_3557 response regulator receiver:transcriptional regulatory protein, C-terminal; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver; transcriptional regulator domain protein.
 
 0.749
Slit_0585
Multi-sensor hybrid histidine kinase; KEGG: pin:Ping_2140 fused multi-sensor protein; PFAM: ATP-binding region ATPase domain protein; response regulator receiver; PAS fold-4 domain protein; histidine kinase A domain protein; Hpt domain protein; SMART: ATP-binding region ATPase domain protein; response regulator receiver; PAS domain containing protein; histidine kinase A domain protein; Hpt domain protein.
  
 
 0.728
Slit_0484
Two component transcriptional regulator, winged helix family; KEGG: sml:Smlt1540 putative two-component system, response regulator transcriptional regulatory protein; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver; transcriptional regulator domain protein.
 
 
 0.720
Slit_1856
PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; 3-hydroxyacyl-CoA dehydrogenase domain protein; Enoyl-CoA hydratase/isomerase; KEGG: nmu:Nmul_A0097 3-hydroxyacyl-CoA dehydrogenase, NAD-binding.
   
 0.697
Slit_0330
Two component transcriptional regulator PhoB, winged helix family; TIGRFAM: phosphate regulon transcriptional regulatory protein PhoB; PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: lhk:LHK_00165 PhoB; SMART: response regulator receiver; transcriptional regulator domain protein.
 
 0.678
Your Current Organism:
Sideroxydans lithotrophicus
NCBI taxonomy Id: 580332
Other names: S. lithotrophicus ES-1, Sideroxydans lithotrophicus ES-1, Sideroxydans lithotrophicus str. ES-1, Sideroxydans lithotrophicus strain ES-1, iron-oxidizing lithotroph ES-1
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