Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cobDCobalamin biosynthesis protein CbiB; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (311 aa)    
Predicted Functional Partners:
Slit_2399
KEGG: bcj:BCAL3286 cobalamin adenosyltransferase protein; TIGRFAM: ATP/cobalamin adenosyltransferase; PFAM: cobalamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family.
 
  
 0.943
cbiA
Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.
 
  
 0.843
Slit_2095
KEGG: app:CAP2UW1_4067 hypothetical protein.
  
     0.657
Slit_2058
KEGG: nmu:Nmul_A2067 hypothetical protein.
  
     0.643
Slit_0269
PFAM: protein of unknown function DUF513 hemX; KEGG: nmu:Nmul_A2688 hypothetical protein.
  
     0.607
cysG
uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
     
 0.528
Slit_0940
KEGG: dar:Daro_3160 hypothetical protein.
  
     0.499
Slit_2407
KEGG: nmu:Nmul_A1053 hypothetical protein.
  
     0.494
Slit_0127
PFAM: Sporulation domain protein; KEGG: cvi:CV_3999 hypothetical protein.
  
     0.480
Slit_1032
Sulfite reductase (ferredoxin); KEGG: nmu:Nmul_A1146 nitrite and sulphite reductase 4Fe-4S region; PFAM: nitrite and sulphite reductase 4Fe-4S region; nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein.
     
 0.466
Your Current Organism:
Sideroxydans lithotrophicus
NCBI taxonomy Id: 580332
Other names: S. lithotrophicus ES-1, Sideroxydans lithotrophicus ES-1, Sideroxydans lithotrophicus str. ES-1, Sideroxydans lithotrophicus strain ES-1, iron-oxidizing lithotroph ES-1
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