Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
Slit_1187PFAM: AMP-dependent synthetase and ligase; KEGG: abo:ABO_1731 acetyl-CoA synthetase. (629 aa)    
Predicted Functional Partners:
Slit_1189
TIGRFAM: 2-methylcitrate synthase/citrate synthase II; KEGG: bgl:bglu_2g21700 citrate synthase; PFAM: Citrate synthase; Belongs to the citrate synthase family.
  
 0.960
acsA
acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
  
 
0.911
Slit_1833
Quinone oxidoreductase, YhdH/YhfP family; KEGG: dar:Daro_1202 zinc-containing alcohol dehydrogenase superfamily protein; TIGRFAM: quinone oxidoreductase, YhdH/YhfP family; PFAM: Alcohol dehydrogenase GroES domain protein; Alcohol dehydrogenase zinc-binding domain protein.
   
 
 0.908
Slit_1850
TIGRFAM: acetyl-CoA acetyltransferase; KEGG: neu:NE1527 acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.868
Slit_1188
TIGRFAM: 2-methylcitrate dehydratase; KEGG: pap:PSPA7_4727 2-methylcitrate dehydratase; PFAM: MmgE/PrpD family protein.
 
  
 0.760
Slit_1540
KEGG: net:Neut_1809 histone deacetylase superfamily protein; PFAM: histone deacetylase superfamily.
 
  
 0.657
Slit_1856
PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; 3-hydroxyacyl-CoA dehydrogenase domain protein; Enoyl-CoA hydratase/isomerase; KEGG: nmu:Nmul_A0097 3-hydroxyacyl-CoA dehydrogenase, NAD-binding.
 
 
 0.640
Slit_2486
PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; 4Fe-4S ferredoxin iron-sulfur binding domain protein; thiamine pyrophosphate protein domain protein TPP-binding; Pyruvate/ketoisovalerate oxidoreductase; KEGG: hha:Hhal_0066 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein.
  
  
 0.627
Slit_1263
Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
 
  
 0.605
prpB
Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
  
  
 0.597
Your Current Organism:
Sideroxydans lithotrophicus
NCBI taxonomy Id: 580332
Other names: S. lithotrophicus ES-1, Sideroxydans lithotrophicus ES-1, Sideroxydans lithotrophicus str. ES-1, Sideroxydans lithotrophicus strain ES-1, iron-oxidizing lithotroph ES-1
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