Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Slit_1234KEGG: tbd:Tbd_2144 transmembrane protein. (243 aa)    
Predicted Functional Partners:
Slit_0703
PFAM: Rieske [2Fe-2S] iron-sulphur domain; KEGG: nmu:Nmul_A0233 Rieske (2Fe-2S) region.
  
     0.631
flhD
Flagellar transcriptional activator; Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhD family.
  
     0.582
Slit_1233
PFAM: 17 kDa surface antigen; KEGG: har:HEAR2232 putative signal peptide.
 
     0.570
Slit_2143
PFAM: major facilitator superfamily MFS_1; KEGG: tbd:Tbd_1718 lysophospholipid transporter LplT.
  
     0.531
flhC
Flagellar transcriptional activator FlhC; Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhC family.
  
     0.515
Slit_0508
PFAM: ribonuclease II; KEGG: net:Neut_0498 ribonuclease II.
  
     0.465
Slit_2058
KEGG: nmu:Nmul_A2067 hypothetical protein.
  
     0.428
Slit_0737
Transcriptional regulator, TetR family; PFAM: regulatory protein TetR; KEGG: dar:Daro_0627 nucleoid occlusion protein.
  
     0.427
Slit_1235
TIGRFAM: aminoacyl-histidine dipeptidase; KEGG: dar:Daro_1720 peptidase M20C, Xaa-His dipeptidase; PFAM: peptidase dimerisation domain protein; peptidase M20.
       0.424
Your Current Organism:
Sideroxydans lithotrophicus
NCBI taxonomy Id: 580332
Other names: S. lithotrophicus ES-1, Sideroxydans lithotrophicus ES-1, Sideroxydans lithotrophicus str. ES-1, Sideroxydans lithotrophicus strain ES-1, iron-oxidizing lithotroph ES-1
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