Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Slit_1391KEGG: mac:MA1988 hypothetical protein. (47 aa)    
Predicted Functional Partners:
Slit_1390
PFAM: Biopolymer transport protein ExbD/TolR; KEGG: rme:Rmet_2279 biopolymer transport protein ExbD/TolR.
       0.548
Slit_1388
TonB family protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family.
       0.541
Slit_1389
PFAM: MotA/TolQ/ExbB proton channel; KEGG: pag:PLES_01991 transport protein ExbB.
       0.541
Slit_1385
KEGG: dar:Daro_2954 hypothetical protein.
       0.457
Slit_1386
PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: dar:Daro_2955 4Fe-4S ferredoxin, iron-sulfur binding.
       0.457
Slit_1387
KEGG: dar:Daro_2956 cytochrome c biogenesis protein, transmembrane region.
       0.457
Slit_1392
KEGG: dia:Dtpsy_3303 NAD(P)(+) transhydrogenase (AB-specific); PFAM: alanine dehydrogenase/PNT domain protein.
       0.431
Slit_1384
PFAM: TonB-dependent receptor; TonB-dependent receptor plug; KEGG: dar:Daro_2953 TonB-dependent receptor.
       0.425
Slit_1393
KEGG: nmu:Nmul_A1152 transmembrane NAD(P) transhydrogenase (alpha subunit part 2).
       0.421
Slit_1394
NAD(P)(+) transhydrogenase (AB-specific); The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.
       0.421
Your Current Organism:
Sideroxydans lithotrophicus
NCBI taxonomy Id: 580332
Other names: S. lithotrophicus ES-1, Sideroxydans lithotrophicus ES-1, Sideroxydans lithotrophicus str. ES-1, Sideroxydans lithotrophicus strain ES-1, iron-oxidizing lithotroph ES-1
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