STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Slit_1618Hypothetical protein; KEGG: cch:Cag_1072 sialic acid synthase. (145 aa)    
Predicted Functional Partners:
Slit_1619
PFAM: protein of unknown function DUF224 cysteine-rich region domain protein; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: tbd:Tbd_1376 heterodisulfide reductase.
       0.773
Slit_1617
PFAM: nickel-dependent hydrogenase large subunit; KEGG: tbd:Tbd_1375 Ni-Fe hydrogenase large chain; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
       0.768
Slit_1620
KEGG: tbd:Tbd_1377 hypothetical protein.
       0.741
Slit_1621
TIGRFAM: hydrogenase (NiFe) small subunit HydA; KEGG: tbd:Tbd_1378 Ni-Fe hydrogenase, small subunit; PFAM: NADH ubiquinone oxidoreductase 20 kDa subunit.
       0.741
Slit_1622
Hydrogenase maturation protease; KEGG: tbd:Tbd_1380 peptidase M52, hydrogen uptake protein; TIGRFAM: hydrogenase maturation protease; hydrogenase assembly chaperone hypC/hupF; PFAM: hydrogenase expression/formation protein (HUPF/HYPC); peptidase M52 hydrogen uptake protein.
       0.561
Slit_1623
PFAM: tRNA/rRNA methyltransferase (SpoU); RNA 2-O ribose methyltransferase substrate binding; KEGG: mfa:Mfla_1107 tRNA/rRNA methyltransferase (SpoU).
       0.454
Slit_1615
TIGRFAM: addiction module antidote protein; PFAM: helix-turn-helix domain protein; KEGG: noc:Noc_0569 Cro/CI family transcriptional regulator; SMART: helix-turn-helix domain protein.
       0.443
Slit_1616
Manually curated; TIGRFAM: addiction module killer protein; KEGG: cpb:Cphamn1_0569 addiction module killer protein; PFAM: protein of unknown function DUF891.
       0.443
Your Current Organism:
Sideroxydans lithotrophicus
NCBI taxonomy Id: 580332
Other names: S. lithotrophicus ES-1, Sideroxydans lithotrophicus ES-1, Sideroxydans lithotrophicus str. ES-1, Sideroxydans lithotrophicus strain ES-1, iron-oxidizing lithotroph ES-1
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