Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Slit_1622Hydrogenase maturation protease; KEGG: tbd:Tbd_1380 peptidase M52, hydrogen uptake protein; TIGRFAM: hydrogenase maturation protease; hydrogenase assembly chaperone hypC/hupF; PFAM: hydrogenase expression/formation protein (HUPF/HYPC); peptidase M52 hydrogen uptake protein. (267 aa)    
Predicted Functional Partners:
Slit_1617
PFAM: nickel-dependent hydrogenase large subunit; KEGG: tbd:Tbd_1375 Ni-Fe hydrogenase large chain; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 0.966
Slit_1621
TIGRFAM: hydrogenase (NiFe) small subunit HydA; KEGG: tbd:Tbd_1378 Ni-Fe hydrogenase, small subunit; PFAM: NADH ubiquinone oxidoreductase 20 kDa subunit.
 
 
 0.965
Slit_2421
KEGG: rfr:Rfer_4099 hydrogenase expression/formation protein HypD; TIGRFAM: hydrogenase expression/formation protein HypD; PFAM: hydrogenase formation HypD protein; Belongs to the HypD family.
 
 
 0.957
Slit_2424
KEGG: rme:Rmet_1536 hydrogenase accessory protein HypB; TIGRFAM: hydrogenase accessory protein HypB; PFAM: cobalamin synthesis protein P47K.
 
  
 0.911
Slit_2419
KEGG: app:CAP2UW1_0735 hydrogenase expression/formation protein HypE; TIGRFAM: hydrogenase expression/formation protein HypE; PFAM: AIR synthase related protein domain protein; AIR synthase related protein.
 
 
 0.910
Slit_2426
KEGG: azo:azo3798 putative hydrogenase expression/formation protein HupK.
 
 
 0.902
Slit_1620
KEGG: tbd:Tbd_1377 hypothetical protein.
 
   
 0.828
hypA
Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
  
 0.819
Slit_2423
(NiFe) hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
 
 0.751
Slit_1619
PFAM: protein of unknown function DUF224 cysteine-rich region domain protein; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: tbd:Tbd_1376 heterodisulfide reductase.
 
   
 0.749
Your Current Organism:
Sideroxydans lithotrophicus
NCBI taxonomy Id: 580332
Other names: S. lithotrophicus ES-1, Sideroxydans lithotrophicus ES-1, Sideroxydans lithotrophicus str. ES-1, Sideroxydans lithotrophicus strain ES-1, iron-oxidizing lithotroph ES-1
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.