Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
Slit_2095KEGG: app:CAP2UW1_4067 hypothetical protein. (1273 aa)    
Predicted Functional Partners:
Slit_2094
PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; KEGG: tbd:Tbd_0511 carbon-nitrogen hydrolase.
 
     0.723
Slit_0269
PFAM: protein of unknown function DUF513 hemX; KEGG: nmu:Nmul_A2688 hypothetical protein.
  
     0.710
Slit_2093
KEGG: nmu:Nmul_A1055 peptidase U62, modulator of DNA gyrase; manually curated; PFAM: peptidase U62 modulator of DNA gyrase.
 
   
 0.705
Slit_2058
KEGG: nmu:Nmul_A2067 hypothetical protein.
  
     0.690
cobD
Cobalamin biosynthesis protein CbiB; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
  
     0.657
Slit_2756
PFAM: protein of unknown function YGGT; KEGG: nmu:Nmul_A0580 hypothetical protein.
  
     0.648
secE
Preprotein translocase, SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family.
  
     0.646
Slit_0127
PFAM: Sporulation domain protein; KEGG: cvi:CV_3999 hypothetical protein.
  
     0.619
Slit_0439
PFAM: protein of unknown function DUF1239; KEGG: mfa:Mfla_0139 hypothetical protein.
  
     0.607
glnE
(Glutamate--ammonia-ligase) adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tra [...]
       0.588
Your Current Organism:
Sideroxydans lithotrophicus
NCBI taxonomy Id: 580332
Other names: S. lithotrophicus ES-1, Sideroxydans lithotrophicus ES-1, Sideroxydans lithotrophicus str. ES-1, Sideroxydans lithotrophicus strain ES-1, iron-oxidizing lithotroph ES-1
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