STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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glnE(Glutamate--ammonia-ligase) adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tra [...] (917 aa)    
Predicted Functional Partners:
glnD
UTP-GlnB uridylyltransferase, GlnD; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
 
   
 0.794
Slit_2923
KEGG: app:CAP2UW1_0248 glutamine synthetase, type I; TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp.
 
   
 0.758
Slit_0066
KEGG: dar:Daro_0054 ammonium transporter; TIGRFAM: ammonium transporter; PFAM: ammonium transporter.
     
 0.658
Slit_1085
PFAM: ammonium transporter; KEGG: rme:Rmet_4750 Rh-like protein/ammonium transporter.
     
 0.658
nifH
Nitrogenase iron protein; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein; Belongs to the NifH/BchL/ChlL family.
      
 0.643
Slit_0445
TIGRFAM: ATP-dependent helicase HrpA; PFAM: protein of unknown function DUF559; helicase domain protein; helicase-associated domain protein; protein of unknown function DUF1605; KEGG: dar:Daro_3426 ATP-dependent helicase HrpA; SMART: DEAD-like helicase; AAA ATPase; helicase domain protein.
  
     0.594
Slit_2095
KEGG: app:CAP2UW1_4067 hypothetical protein.
       0.588
nadE
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
     
 0.524
Slit_0115
KEGG: mei:Msip34_2803 glutamate synthase (ferredoxin); PFAM: glutamate synthase; ferredoxin-dependent glutamate synthase; glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein.
     
 0.513
Slit_2094
PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; KEGG: tbd:Tbd_0511 carbon-nitrogen hydrolase.
     
 0.510
Your Current Organism:
Sideroxydans lithotrophicus
NCBI taxonomy Id: 580332
Other names: S. lithotrophicus ES-1, Sideroxydans lithotrophicus ES-1, Sideroxydans lithotrophicus str. ES-1, Sideroxydans lithotrophicus strain ES-1, iron-oxidizing lithotroph ES-1
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