Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Slit_2180KEGG: rpf:Rpic12D_1115 MATE efflux family protein; TIGRFAM: MATE efflux family protein; PFAM: multi antimicrobial extrusion protein MatE. (456 aa)    
Predicted Functional Partners:
Slit_0015
SMART: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; KEGG: mfa:Mfla_2248 glyceraldehyde-3-phosphate dehydrogenase; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
   
  
 0.680
Slit_2060
Ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.
   
    0.657
Slit_1436
TIGRFAM: squalene synthase HpnD; KEGG: app:CAP2UW1_3259 squalene synthase HpnD; PFAM: Squalene/phytoene synthase.
   
  
 0.644
Slit_1437
TIGRFAM: squalene synthase HpnC; KEGG: eba:ebA6809 terpenoid synthase-related protein; PFAM: Squalene/phytoene synthase.
   
  
 0.644
rplO
Ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.
  
 
   0.643
Slit_2181
Hypothetical protein.
       0.603
Slit_2179
KEGG: azo:azo0016 hypothetical protein.
       0.529
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.477
Slit_2178
PFAM: protein of unknown function DUF336; KEGG: tgr:Tgr7_2753 hypothetical protein.
       0.477
Slit_1160
KEGG: mgm:Mmc1_3164 multi-sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; response regulator receiver; Hpt domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; response regulator receiver; Hpt domain protein.
  
 
 0.464
Your Current Organism:
Sideroxydans lithotrophicus
NCBI taxonomy Id: 580332
Other names: S. lithotrophicus ES-1, Sideroxydans lithotrophicus ES-1, Sideroxydans lithotrophicus str. ES-1, Sideroxydans lithotrophicus strain ES-1, iron-oxidizing lithotroph ES-1
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