STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Slit_2224PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: nmu:Nmul_A1944 putative 6-pyruvoyl tetrahydropterin synthase. (146 aa)    
Predicted Functional Partners:
queE
Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
 
 
 0.995
queC
exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
 
  
 0.955
folE2
Protein of unknown function DUF198; Converts GTP to 7,8-dihydroneopterin triphosphate.
    
 0.923
Slit_0976
PFAM: NUDIX hydrolase; KEGG: neu:NE2253 dATP pyrophosphohydrolase.
    
  0.900
queF
7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
 
  
 0.884
Slit_2222
PFAM: protein of unknown function DUF58; KEGG: tmz:Tmz1t_3010 protein of unknown function DUF58.
  
    0.672
Slit_2223
KEGG: app:CAP2UW1_1368 transglutaminase domain protein; PFAM: transglutaminase domain protein; SMART: transglutaminase domain protein.
       0.671
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
     
 0.474
Slit_0063
PFAM: protein of unknown function DUF526; KEGG: mms:mma_0167 hypothetical protein.
  
     0.468
cysS
SMART: Cysteinyl-tRNA synthetase class Ia DALR; TIGRFAM: cysteinyl-tRNA synthetase; KEGG: tmz:Tmz1t_3046 cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase class Ia; Cysteinyl-tRNA synthetase class Ia DALR; Belongs to the class-I aminoacyl-tRNA synthetase family.
   
  
 0.464
Your Current Organism:
Sideroxydans lithotrophicus
NCBI taxonomy Id: 580332
Other names: S. lithotrophicus ES-1, Sideroxydans lithotrophicus ES-1, Sideroxydans lithotrophicus str. ES-1, Sideroxydans lithotrophicus strain ES-1, iron-oxidizing lithotroph ES-1
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