Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Slit_2226TIGRFAM: diguanylate cyclase; PAS sensor protein; PFAM: GGDEF domain containing protein; histidine kinase HAMP region domain protein; PAS fold domain protein; PAS fold-4 domain protein; KEGG: dar:Daro_4048 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); SMART: GGDEF domain containing protein; histidine kinase HAMP region domain protein; PAS domain containing protein; PAC repeat-containing protein. (1080 aa)    
Predicted Functional Partners:
Slit_1160
KEGG: mgm:Mmc1_3164 multi-sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; response regulator receiver; Hpt domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; response regulator receiver; Hpt domain protein.
 
 
 0.972
Slit_0584
KEGG: pol:Bpro_2469 response regulator receiver/diguanylate phosphodiesterase; PFAM: EAL domain protein; response regulator receiver; SMART: EAL domain protein; response regulator receiver.
 
 
 0.940
Slit_0286
Diguanylate phosphodiesterase; KEGG: bba:Bd1971 hypothetical protein; PFAM: EAL domain protein; cyclic nucleotide-binding; SMART: EAL domain protein; cyclic nucleotide-binding.
 
 
 0.898
Slit_0585
Multi-sensor hybrid histidine kinase; KEGG: pin:Ping_2140 fused multi-sensor protein; PFAM: ATP-binding region ATPase domain protein; response regulator receiver; PAS fold-4 domain protein; histidine kinase A domain protein; Hpt domain protein; SMART: ATP-binding region ATPase domain protein; response regulator receiver; PAS domain containing protein; histidine kinase A domain protein; Hpt domain protein.
 
 
 0.883
Slit_1289
KEGG: tgr:Tgr7_0082 Hpt sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; response regulator receiver; histidine kinase A domain protein; Hpt domain protein; SMART: ATP-binding region ATPase domain protein; response regulator receiver; histidine kinase A domain protein; Hpt domain protein.
 
 
 0.875
Slit_1184
Diguanylate phosphodiesterase; TIGRFAM: PAS sensor protein; PFAM: EAL domain protein; PAS fold-4 domain protein; KEGG: net:Neut_1199 diguanylate phosphodiesterase; SMART: EAL domain protein; PAS domain containing protein; PAC repeat-containing protein.
 
 
 0.841
Slit_2582
KEGG: bvi:Bcep1808_3360 integral membrane sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; response regulator receiver; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; response regulator receiver.
  
 
 0.793
Slit_1298
TIGRFAM: diguanylate cyclase; PFAM: EAL domain protein; GGDEF domain containing protein; response regulator receiver; KEGG: drm:Dred_1346 diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s); SMART: EAL domain protein; GGDEF domain containing protein; response regulator receiver.
 
 
0.787
Slit_0663
Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); TIGRFAM: diguanylate cyclase; PAS sensor protein; PFAM: EAL domain protein; GGDEF domain containing protein; PAS fold domain protein; KEGG: dar:Daro_3099 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); SMART: EAL domain protein; GGDEF domain containing protein; PAC repeat-containing protein; PAS domain containing protein.
 
 
0.784
Slit_2227
Manually curated; TIGRFAM: phage SPO1 DNA polymerase-related protein; KEGG: nmu:Nmul_A2121 phage SPO1 DNA polymerase-related protein; PFAM: Uracil-DNA glycosylase superfamily.
       0.773
Your Current Organism:
Sideroxydans lithotrophicus
NCBI taxonomy Id: 580332
Other names: S. lithotrophicus ES-1, Sideroxydans lithotrophicus ES-1, Sideroxydans lithotrophicus str. ES-1, Sideroxydans lithotrophicus strain ES-1, iron-oxidizing lithotroph ES-1
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