Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Slit_2357KEGG: nmu:Nmul_A0586 hypothetical protein; PFAM: TPR repeat-containing protein; SMART: Tetratricopeptide repeat. (591 aa)    
Predicted Functional Partners:
Slit_2622
Carboxyl-terminal protease; SMART: peptidase S41; PDZ/DHR/GLGF domain protein; TIGRFAM: carboxyl-terminal protease; KEGG: mei:Msip34_0439 carboxyl-terminal protease; PFAM: peptidase S41; PDZ/DHR/GLGF domain protein; Belongs to the peptidase S41A family.
 
 
 0.899
lolB
Outer membrane lipoprotein LolB; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
 
    0.847
ispE
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
       0.808
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
 
    0.619
Slit_0507
TIGRFAM: TonB family protein; KEGG: neu:NE1626 putative TonB protein.
 
     0.502
Slit_2358
Manually curated; TIGRFAM: RND efflux system, outer membrane lipoprotein, NodT family; KEGG: mms:mma_0285 outer membrane protein, TolC-like; PFAM: outer membrane efflux protein.
       0.484
Slit_2621
PFAM: Peptidase M23; KEGG: nmu:Nmul_A1120 peptidase M23B.
  
 
 0.465
Slit_0686
PFAM: Tetratricopeptide TPR_2 repeat protein; TPR repeat-containing protein; KEGG: app:CAP2UW1_0625 tetratricopeptide TPR_2 repeat protein.
  
 
 0.449
Slit_1740
SMART: Tetratricopeptide repeat; KEGG: glo:Glov_1853 tetratricopeptide TPR_2 repeat protein.
  
 
 0.449
Slit_2361
PFAM: ABC-type uncharacterised transport system; KEGG: nmu:Nmul_A0583 hypothetical protein.
 
     0.427
Your Current Organism:
Sideroxydans lithotrophicus
NCBI taxonomy Id: 580332
Other names: S. lithotrophicus ES-1, Sideroxydans lithotrophicus ES-1, Sideroxydans lithotrophicus str. ES-1, Sideroxydans lithotrophicus strain ES-1, iron-oxidizing lithotroph ES-1
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