Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Slit_2382Carboxylesterase; KEGG: azo:azo2859 carboxylesterase; PFAM: phospholipase/Carboxylesterase. (229 aa)    
Predicted Functional Partners:
Slit_2662
TIGRFAM: molybdenum cofactor synthesis domain protein; PFAM: molybdopterin binding domain; KEGG: sdl:Sdel_1336 molybdenum cofactor synthesis domain protein; SMART: molybdopterin binding domain.
 
    0.808
Slit_1458
PFAM: Extradiol ring-cleavage dioxygenase class III protein subunit B; KEGG: bra:BRADO5603 putative extradiol ring-cleavage dioxygenase.
      0.698
Slit_0122
PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; KEGG: gvi:gvip312 ferredoxin--NADP+ reductase.
     
  0.635
Slit_2381
TIGRFAM: PAS sensor protein; PFAM: PAS fold domain protein; KEGG: dar:Daro_4009 PAS; SMART: PAC repeat-containing protein; PAS domain containing protein.
       0.536
Slit_0002
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
    
   0.426
Slit_2775
PFAM: short-chain dehydrogenase/reductase SDR; KEGG: mxa:MXAN_0865 short chain dehydrogenase/reductase family oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
  
 
 0.401
Your Current Organism:
Sideroxydans lithotrophicus
NCBI taxonomy Id: 580332
Other names: S. lithotrophicus ES-1, Sideroxydans lithotrophicus ES-1, Sideroxydans lithotrophicus str. ES-1, Sideroxydans lithotrophicus strain ES-1, iron-oxidizing lithotroph ES-1
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