STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Coexpression
Experiments
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[Homology]
Score
hypAHydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (113 aa)    
Predicted Functional Partners:
Slit_2424
KEGG: rme:Rmet_1536 hydrogenase accessory protein HypB; TIGRFAM: hydrogenase accessory protein HypB; PFAM: cobalamin synthesis protein P47K.
 
 
 0.987
Slit_2426
KEGG: azo:azo3798 putative hydrogenase expression/formation protein HupK.
 
 
 0.979
Slit_2421
KEGG: rfr:Rfer_4099 hydrogenase expression/formation protein HypD; TIGRFAM: hydrogenase expression/formation protein HypD; PFAM: hydrogenase formation HypD protein; Belongs to the HypD family.
 
  
 0.961
Slit_2422
Hydrogenase assembly chaperone hypC/hupF; KEGG: dar:Daro_3967 hydrogenase expression/formation protein (HUPF/HYPC); TIGRFAM: hydrogenase assembly chaperone hypC/hupF; PFAM: hydrogenase expression/formation protein (HUPF/HYPC).
 
  
 0.958
Slit_2423
(NiFe) hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
   
 0.942
Slit_1617
PFAM: nickel-dependent hydrogenase large subunit; KEGG: tbd:Tbd_1375 Ni-Fe hydrogenase large chain; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 0.931
Slit_2419
KEGG: app:CAP2UW1_0735 hydrogenase expression/formation protein HypE; TIGRFAM: hydrogenase expression/formation protein HypE; PFAM: AIR synthase related protein domain protein; AIR synthase related protein.
 
  
 0.851
Slit_1622
Hydrogenase maturation protease; KEGG: tbd:Tbd_1380 peptidase M52, hydrogen uptake protein; TIGRFAM: hydrogenase maturation protease; hydrogenase assembly chaperone hypC/hupF; PFAM: hydrogenase expression/formation protein (HUPF/HYPC); peptidase M52 hydrogen uptake protein.
 
  
 0.820
Slit_1621
TIGRFAM: hydrogenase (NiFe) small subunit HydA; KEGG: tbd:Tbd_1378 Ni-Fe hydrogenase, small subunit; PFAM: NADH ubiquinone oxidoreductase 20 kDa subunit.
 
  
 0.805
Slit_2672
ATPase-like, ParA/MinD; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.
   
   0.766
Your Current Organism:
Sideroxydans lithotrophicus
NCBI taxonomy Id: 580332
Other names: S. lithotrophicus ES-1, Sideroxydans lithotrophicus ES-1, Sideroxydans lithotrophicus str. ES-1, Sideroxydans lithotrophicus strain ES-1, iron-oxidizing lithotroph ES-1
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