Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Slit_2624TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; KEGG: hch:HCH_04724 response regulator; SMART: GGDEF domain containing protein. (355 aa)    
Predicted Functional Partners:
Slit_0889
KEGG: rfr:Rfer_2293 metal dependent phosphohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region.
 
 
   0.925
Slit_0299
KEGG: rfr:Rfer_3638 metal dependent phosphohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region.
 
 
   0.908
Slit_1163
KEGG: mag:amb1840 response regulator; PFAM: response regulator receiver; SMART: response regulator receiver.
 
 
    0.900
Slit_0584
KEGG: pol:Bpro_2469 response regulator receiver/diguanylate phosphodiesterase; PFAM: EAL domain protein; response regulator receiver; SMART: EAL domain protein; response regulator receiver.
 
  
 0.810
Slit_2271
TIGRFAM: diguanylate cyclase; PFAM: EAL domain protein; Autoinducer-binding domain protein; regulatory protein LuxR; GGDEF domain containing protein; KEGG: tau:Tola_0479 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); SMART: EAL domain protein; GGDEF domain containing protein; regulatory protein LuxR.
  
  
 0.799
Slit_0286
Diguanylate phosphodiesterase; KEGG: bba:Bd1971 hypothetical protein; PFAM: EAL domain protein; cyclic nucleotide-binding; SMART: EAL domain protein; cyclic nucleotide-binding.
 
   0.797
Slit_1237
TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; Diverse 7TM receptor transmembrane region; KEGG: mei:Msip34_1112 7TM domain sensor diguanylate cyclase; SMART: GGDEF domain containing protein.
  
     0.770
Slit_1184
Diguanylate phosphodiesterase; TIGRFAM: PAS sensor protein; PFAM: EAL domain protein; PAS fold-4 domain protein; KEGG: net:Neut_1199 diguanylate phosphodiesterase; SMART: EAL domain protein; PAS domain containing protein; PAC repeat-containing protein.
 
   0.739
Slit_1290
KEGG: tgr:Tgr7_0081 two component transcriptional regulator, AraC family; PFAM: metal-dependent phosphohydrolase HD sub domain; response regulator receiver; SMART: response regulator receiver; metal-dependent phosphohydrolase HD region.
 
    0.606
Slit_1313
KEGG: mag:amb1840 response regulator; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region.
 
    0.557
Your Current Organism:
Sideroxydans lithotrophicus
NCBI taxonomy Id: 580332
Other names: S. lithotrophicus ES-1, Sideroxydans lithotrophicus ES-1, Sideroxydans lithotrophicus str. ES-1, Sideroxydans lithotrophicus strain ES-1, iron-oxidizing lithotroph ES-1
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