Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Slit_2797PFAM: dUTPase; KEGG: amc:MADE_01024 leucyl/phenylalanyl-tRNA--protein transferase. (232 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
    
 0.538
Slit_2798
Hypothetical protein; KEGG: chl:Chy400_0438 conserved repeat domain protein.
       0.532
ndk
Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
     
  0.500
Slit_1780
PFAM: protein of unknown function DUF6 transmembrane; KEGG: eba:ebA4464 hypothetical protein.
  
     0.449
Slit_2796
KEGG: bvi:Bcep1808_2979 YecA family protein; TIGRFAM: yecA family protein; PFAM: SEC-C motif domain protein.
       0.439
Slit_0743
PFAM: conserved hypothetical protein; KEGG: mei:Msip34_2317 hypothetical protein.
  
     0.413
Slit_2839
KEGG: net:Neut_1369 hypothetical protein.
  
     0.400
Your Current Organism:
Sideroxydans lithotrophicus
NCBI taxonomy Id: 580332
Other names: S. lithotrophicus ES-1, Sideroxydans lithotrophicus ES-1, Sideroxydans lithotrophicus str. ES-1, Sideroxydans lithotrophicus strain ES-1, iron-oxidizing lithotroph ES-1
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