Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
thrBTIGRFAM: homoserine kinase; KEGG: neu:NE1471 homoserine kinase; PFAM: aminoglycoside phosphotransferase; Belongs to the pseudomonas-type ThrB family. (313 aa)    
Predicted Functional Partners:
Slit_2218
KEGG: azo:azo2081 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding.
 
  
 0.927
Slit_2217
TIGRFAM: threonine synthase; KEGG: dar:Daro_2382 threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit.
    
 0.917
Slit_2835
KEGG: tbd:Tbd_2451 hypothetical protein.
  
    0.852
Slit_0060
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
    
  0.806
Slit_1781
PFAM: aminotransferase class I and II; KEGG: mca:MCA1021 aminotransferase, classes I and II.
   
 
  0.806
ilvE
Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
     
 0.803
metZ
O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide.
     
 0.802
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
    
  0.800
Slit_0808
Manually curated; TIGRFAM: serine O-acetyltransferase; KEGG: mca:MCA1830 serine acetyltransferase.
     
  0.800
Slit_2257
KEGG: tbd:Tbd_1162 serine O-acetyltransferase; TIGRFAM: serine O-acetyltransferase.
     
  0.800
Your Current Organism:
Sideroxydans lithotrophicus
NCBI taxonomy Id: 580332
Other names: S. lithotrophicus ES-1, Sideroxydans lithotrophicus ES-1, Sideroxydans lithotrophicus str. ES-1, Sideroxydans lithotrophicus strain ES-1, iron-oxidizing lithotroph ES-1
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