Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
ntrCNitrogen metabolism transcriptional regulator, NtrC, Fis Family; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (466 aa)    
Predicted Functional Partners:
Slit_2925
KEGG: mei:Msip34_2494 signal transduction histidine kinase, nitrogen specific, NtrB; PFAM: ATP-binding region ATPase domain protein; PAS fold-4 domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS domain containing protein.
 0.996
Slit_0436
RNA polymerase, sigma 54 subunit, RpoN; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
   
 0.783
Slit_2924
KEGG: mfa:Mfla_2448 hypothetical protein.
       0.648
Slit_0019
PFAM: cytochrome c class I; KEGG: mei:Msip34_0374 cytochrome c class I.
      
 0.618
Slit_0510
PFAM: cytochrome c class I; KEGG: dar:Daro_3321 cytochrome c, class I.
      
 0.618
Slit_1770
PFAM: cytochrome c class I; KEGG: tmz:Tmz1t_3728 cytochrome c class I.
      
 0.618
Slit_2498
PFAM: cytochrome c class I; KEGG: dar:Daro_1401 cytochrome c, class I.
      
 0.618
Slit_2693
PFAM: cytochrome c class I; KEGG: mmb:Mmol_0398 cytochrome c class I.
      
 0.618
Slit_2694
PFAM: cytochrome c class I; KEGG: mei:Msip34_0374 cytochrome c class I.
      
 0.618
Slit_2780
KEGG: mmb:Mmol_0398 cytochrome c class I.
      
 0.618
Your Current Organism:
Sideroxydans lithotrophicus
NCBI taxonomy Id: 580332
Other names: S. lithotrophicus ES-1, Sideroxydans lithotrophicus ES-1, Sideroxydans lithotrophicus str. ES-1, Sideroxydans lithotrophicus strain ES-1, iron-oxidizing lithotroph ES-1
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