STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cobTNicotinate-nucleotide/dimethylbenzimidazolephosp horibosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (349 aa)    
Predicted Functional Partners:
Tlie_0148
PFAM: Cobinamide kinase / cobinamide phosphate guanyltransferase; COGs: COG2087 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase; InterPro IPR003203; KEGG: dae:Dtox_3094 adenosylcobinamide-phosphateguanylyltransferase; PFAM: cobalbumin biosynthesis protein; PRIAM: Adenosylcobinamide-phosphate guanylyltransferase; SPTR:Adenosylcobinamide-phosphateguanylyltransferas e.
  
 0.996
cobS
Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
 
 
 0.962
Tlie_0146
PFAM: Phosphoglycerate mutase family; TIGRFAM: alpha-ribazole phosphatase; COGs: COG0406 Fructose-2 6-bisphosphatase; InterPro IPR017578: IPR001345: IPR013078; KEGG: slp:Slip_1453 phosphoglycerate mutase; PFAM: Phosphoglycerate mutase; SPTR: Phosphoglycerate mutase; TIGRFAM: alpha-ribazole phosphatase.
 
 
 0.954
Tlie_0542
PFAM: Phosphoglycerate mutase family; TIGRFAM: alpha-ribazole phosphatase; COGs: COG0406 Fructose-2 6-bisphosphatase; InterPro IPR013078: IPR001345; KEGG: aco:Amico_1510 phosphoglycerate mutase; PFAM: Phosphoglycerate mutase; SPTR: Phosphoglycerate mutase.
  
 
 0.925
cobQ
Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
 
  
 0.881
cobD
Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
 
  
 0.820
Tlie_0162
PFAM: Aminotransferase class I and II; TIGRFAM: L-threonine-O-3-phosphate decarboxylase; histidinol-phosphate aminotransferase; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR001176: IPR005860: IPR004839; KEGG: tjr:TherJR_1312 L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; SPTR: L-threonine-O-3-phosphate decarboxylase; TIGRFAM: L-threonine-O-3-phosphate decarboxylase.
  
 0.634
Tlie_0163
PFAM: GHMP kinases N terminal domain; COGs: COG4542 Protein involved in propanediol utilization and related protein (includes coumermycin biosynthetic protein) possible kinase; InterPro IPR006204: IPR013750: IPR012363; KEGG: cdl:CDR20291_3253 putative cobalamin biosynthesis kinase; PFAM: GHMP kinase; GHMP kinase domain protein; SPTR: Probable cobalamin biosynthesis kinase.
 
  
 0.591
Tlie_0291
PFAM: Pterin binding enzyme; B12 binding domain; Homocysteine S-methyltransferase; TIGRFAM: methylmalonyl-CoA mutase C-terminal domain; COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR003726: IPR000489: IPR003759: IPR006158; KEGG: tai:Taci_0141 homocysteine S-methyltransferase; PFAM: homocysteine S-methyltransferase; dihydropteroate synthase DHPS; Methionine synthase B12-binding module cap domain protein; cobalamin B12-binding domain protein; SPTR: Vitamin B12-dependent methionine synthase family protein.
      
 0.463
Tlie_0286
PFAM: Aminotransferase class I and II; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR004838: IPR004839; KEGG: tsi:TSIB_1557 hypothetical protein; PFAM: aminotransferase class I and II; SPTR: Aminotransferase class I and II.
  
  
 0.446
Your Current Organism:
Thermovirga lienii
NCBI taxonomy Id: 580340
Other names: T. lienii DSM 17291, Thermovirga lienii DSM 17291, Thermovirga lienii str. DSM 17291, Thermovirga lienii strain DSM 17291
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