STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tlie_0262PFAM: CRISPR-associated protein TM1802 (cas_TM1802); KEGG: tjr:TherJR_2494 hypothetical protein; SPTR: Putative uncharacterized protein. (135 aa)    
Predicted Functional Partners:
Tlie_0261
PFAM: CRISPR-associated protein TM1802 (cas_TM1802); InterPro IPR013389; KEGG: tjr:TherJR_2495 CRISPR-associated protein TM1802 family; PFAM: CRISPR-associated protein TM1802; SPTR: Putative uncharacterized protein.
      0.887
Tlie_0260
CRISPR-associated protein, Cas6 family; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
       0.784
Tlie_0264
CRISPR-associated protein, Cas5h family; PFAM: CRISPR-associated protein (Cas_Cas5); TIGRFAM: CRISPR-associated protein Cas5, subtype I-B/HMARI; CRISPR-associated protein Cas5, N-terminal domain; InterPro IPR013422: IPR013421; KEGG: tjr:TherJR_2492 CRISPR-associated protein Cas5, Hmari subtype; SPTR: CRISPR-associated protein Cas5, Hmari subtype; TIGRFAM: CRISPR-associated protein Cas5, Hmari subtype; CRISPR-associated protein Cas5.
       0.694
Tlie_0263
PFAM: Family of unknown function (DUF694); TIGRFAM: CRISPR-associated protein, CT1132 family; CRISPR-associated protein Cas7/Csh2, subtype I-B/HMARI; COGs: COG3649 Uncharacterized protein predicted to be involved in DNA repair; InterPro IPR006482: IPR013419; KEGG: tjr:TherJR_2493 CRISPR-associated protein, Csh2 family; PFAM: CRISPR-associated protein TM1801; SPTR: CRISPR-associated protein, Csh2 family; TIGRFAM: CRISPR-associated protein, Csh2 family; CRISPR-associated protein, CT1132 family.
       0.684
Tlie_0265
CRISPR-associated helicase, Cas3 family; PFAM: HD domain; DEAD/DEAH box helicase; TIGRFAM: CRISPR-associated helicase Cas3; CRISPR-associated endonuclease Cas3-HD; COGs: COG1203 helicase; InterPro IPR006483: IPR006474: IPR001650; KEGG: tjr:TherJR_2491 metal dependent phosphohydrolase; PFAM: helicase domain protein; SPTR: Metal dependent phosphohydrolase; TIGRFAM: CRISPR-associated HD domain protein; CRISPR-associated helicase Cas3; manually curated.
       0.684
Tlie_0266
CRISPR-associated protein Cas4; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family.
       0.684
cas1
CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
       0.680
cas2-3
CRISPR-associated protein, Cas2 family; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
       0.680
Tlie_0259
ATPase, P-type (transporting), HAD superfamily, subfamily IC; PFAM: E1-E2 ATPase; Cation transporting ATPase, C-terminus; Cation transporter/ATPase, N-terminus; haloacid dehalogenase-like hydrolase; TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; COGs: COG0474 Cation transport ATPase; InterProIPR001757: IPR006069: IPR018303: IPR004014: IPR 008250: IPR005834: IPR006068; KEGG: mmz:MmarC7_1737 ATPase, P-type (transporting), HAD superfamily, subfamily IC; PFAM: E1-E2 ATPase-associated domain protein; cation transporting ATPase domain protein; Haloacid dehalogenase do [...]
       0.499
Your Current Organism:
Thermovirga lienii
NCBI taxonomy Id: 580340
Other names: T. lienii DSM 17291, Thermovirga lienii DSM 17291, Thermovirga lienii str. DSM 17291, Thermovirga lienii strain DSM 17291
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.