STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pxpALamB/YcsF family protein; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. (257 aa)    
Predicted Functional Partners:
Tlie_0280
PFAM: Allophanate hydrolase subunit 1; TIGRFAM: TIGR00370 family protein; COGs: COG2049 Allophanate hydrolase subunit 1; InterPro IPR003833: IPR010016; KEGG: aco:Amico_0496 allophanate hydrolase subunit 1; PFAM: Allophanate hydrolase subunit 1; SMART: Allophanate hydrolase subunit 1; SPTR: Allophanate hydrolase, subunit 1.
  
 0.999
Tlie_0279
Urea amidolyase related protein; PFAM: Allophanate hydrolase subunit 2; TIGRFAM: biotin-dependent carboxylase uncharacterized domain; COGs: COG1984 Allophanate hydrolase subunit 2; InterPro IPR003778; KEGG: aco:Amico_0497 UreA amidolyase related protein; PFAM: Allophanate hydrolase subunit 2; PRIAM: Urea carboxylase; SMART: Allophanate hydrolase subunit 2; SPTR: Urea amidolyase related protein; TIGRFAM: urea amidolyase related protein.
  
 0.998
Tlie_0277
PFAM: Protein of unknown function (DUF1445); COGs: COG4336 conserved hypothetical protein; InterPro IPR009906: IPR016938; KEGG: aco:Amico_0499 protein of unknown function DUF1445; PFAM: protein of unknown function DUF1445; SPTR: Putative uncharacterized protein; Belongs to the D-glutamate cyclase family.
 
    0.956
Tlie_1762
Gamma-glutamyltransferase; PFAM: Gamma-glutamyltranspeptidase; TIGRFAM: gamma-glutamyltranspeptidase; COGs: COG0405 Gamma-glutamyltransferase; InterPro IPR000101; KEGG: tai:Taci_0138 gamma-glutamyltransferase; PFAM: gamma-glutamyltranspeptidase; PRIAM: Gamma-glutamyltransferase; SPTR: Gamma-glutamyltransferase; TIGRFAM: gamma-glutamyltransferase.
     
  0.900
Tlie_0281
Transmembrane transport protein; PFAM: Natural resistance-associated macrophage protein; COGs: COG1914 Mn2+ and Fe2+ transporter of the NRAMP family; KEGG: tai:Taci_0711 transmembrane transport protein; SPTR: Transporter.
  
 0.838
glsA
L-glutaminase; PFAM: Glutaminase; TIGRFAM: glutaminase A; COGs: COG2066 Glutaminase; InterPro IPR015868; KEGG: tai:Taci_0795 glutaminase; PFAM: Glutaminase, core; PRIAM: Glutaminase; SPTR: Glutaminase; TIGRFAM: Glutaminase, core; Belongs to the glutaminase family.
     
  0.800
Tlie_0822
PFAM: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; COGs: COG0334 Glutamate dehydrogenase/leucine dehydrogenase; InterPro IPR014362: IPR006095: IPR006097: IPR006096; KEGG: mvn:Mevan_1556 glutamate dehydrogenase; PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; PRIAM: Glutamate dehydrogenase (NADP(+)); SPTR: Glutamate dehydrogenase (NADP(+)); Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
    
  0.800
purQ
Phosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...]
     
  0.800
Tlie_1318
PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase type III N terminal; COGs: COG3968 Uncharacterized protein related to glutamine synthetase; InterPro IPR008146; KEGG: aco:Amico_1415 glutamine synthetase catalytic region; PFAM: glutamine synthetase catalytic region; SPTR: Glutamine synthetase catalytic region.
     
  0.800
Tlie_0249
PFAM: Citrate synthase; COGs: COG0372 Citrate synthase; InterPro IPR002020; KEGG: tai:Taci_0447 citrate synthase-like protein; PFAM: Citrate synthase; SPTR: Citrate synthase-like protein.
   
    0.704
Your Current Organism:
Thermovirga lienii
NCBI taxonomy Id: 580340
Other names: T. lienii DSM 17291, Thermovirga lienii DSM 17291, Thermovirga lienii str. DSM 17291, Thermovirga lienii strain DSM 17291
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