STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (815 aa)    
Predicted Functional Partners:
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 
 0.999
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
  
 0.849
psd
Phosphatidylserine decarboxylase related protein; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
  
  
 0.829
Tlie_0395
PFAM: CDP-alcohol phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol--serine O-phosphatidyltransferase; COGs: COG1183 Phosphatidylserine synthase; InterPro IPR000462: IPR004533; KEGG: aco:Amico_0254 CDP-diacylglycerol/serineO-phosphatidyl transferase; PFAM: CDP-alcohol phosphatidyltransferase; SPTR: CDP-diacylglycerol/serineO-phosphatidyl transferase; TIGRFAM: CDP-diacylglycerol/serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
       0.824
folD
5, 10-methylenetetrahydrofolate dehydrogenase (NADP+), methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.786
nusA
NusA antitermination factor; Participates in both transcription termination and antitermination.
 
  
 0.779
Tlie_0070
Flagellar hook-associated protein 3; PFAM: Bacterial flagellin N-terminal helical region; Bacterial flagellin C-terminal helical region; TIGRFAM: flagellar hook-associated protein 3; COGs: COG1344 Flagellin and related hook-associated protein; InterPro IPR013384: IPR001492; KEGG: tai:Taci_0666 flagellin domain protein; PFAM: flagellin domain protein; SPTR: Flagellin domain protein; TIGRFAM: flagellar hook-associated protein 3.
    
 
 0.673
Tlie_0130
Flagellin domain protein; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
    
 
 0.673
rplD
LSU ribosomal protein L4P; Forms part of the polypeptide exit tunnel.
   
  
 0.640
fliE
PFAM: Flagellar hook-basal body complex protein FliE; TIGRFAM: flagellar hook-basal body complex protein FliE; InterPro IPR001624; KEGG: tnp:Tnap_1437 flagellar hook-basal body complex subunit FliE; PFAM: flagellar hook-basal body complex protein FliE; SPTR: Flagellar hook-basal body complex protein FliE; TIGRFAM: flagellar hook-basal body complex subunit FliE.
    
 
 0.634
Your Current Organism:
Thermovirga lienii
NCBI taxonomy Id: 580340
Other names: T. lienii DSM 17291, Thermovirga lienii DSM 17291, Thermovirga lienii str. DSM 17291, Thermovirga lienii strain DSM 17291
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.