node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tlie_0002 | Tlie_0706 | Tlie_0002 | Tlie_0706 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | PFAM: DEAD/DEAH box helicase; COGs: COG1199 Rad3-related DNA helicase; InterProIPR014013: IPR001650: IPR011545: IPR014001: IPR 006554: IPR006555; KEGG: aco:Amico_0691 helicase C2; PFAM: DEAD/DEAH box helicase domain protein; SMART: helicase c2; DEAD-like helicase; Helicase-like, DEXD box c2 type; SPTR: Helicase c2. | 0.904 |
Tlie_0002 | Tlie_1082 | Tlie_0002 | Tlie_1082 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | KEGG: aco:Amico_1052 DNA polymerase III gamma/tau subunits-like protein; SPTR: DNA polymerase III gamma/tau subunits-like protein. | 0.998 |
Tlie_0002 | Tlie_1197 | Tlie_0002 | Tlie_1197 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; PFAM: 5'-3' exonuclease, C-terminal SAM fold; DNA polymerase family A; 5'-3' exonuclease, N-terminal resolvase-like domain; TIGRFAM: DNA polymerase I; COGs: COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains; InterProIPR019760: IPR002421: IPR008918: IPR001098: IPR 002298: IPR018320: IPR020046: IPR020047; KEGG: aco:Amico_1259 DNA polymerase I; PFAM: DNA-directed DNA polymerase; 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; PRIAM: DNA-directed DNA polymerase; SMART: 5'-3' exonuclease; Helix-hairpin-helix domain [...] | 0.992 |
Tlie_0002 | recA | Tlie_0002 | Tlie_0853 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.928 |
Tlie_0002 | sbcD | Tlie_0002 | Tlie_0467 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Exodeoxyribonuclease I subunit D; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. | 0.863 |
Tlie_0002 | topA | Tlie_0002 | Tlie_0531 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.928 |
Tlie_0706 | Tlie_0002 | Tlie_0706 | Tlie_0002 | PFAM: DEAD/DEAH box helicase; COGs: COG1199 Rad3-related DNA helicase; InterProIPR014013: IPR001650: IPR011545: IPR014001: IPR 006554: IPR006555; KEGG: aco:Amico_0691 helicase C2; PFAM: DEAD/DEAH box helicase domain protein; SMART: helicase c2; DEAD-like helicase; Helicase-like, DEXD box c2 type; SPTR: Helicase c2. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.904 |
Tlie_0706 | Tlie_1082 | Tlie_0706 | Tlie_1082 | PFAM: DEAD/DEAH box helicase; COGs: COG1199 Rad3-related DNA helicase; InterProIPR014013: IPR001650: IPR011545: IPR014001: IPR 006554: IPR006555; KEGG: aco:Amico_0691 helicase C2; PFAM: DEAD/DEAH box helicase domain protein; SMART: helicase c2; DEAD-like helicase; Helicase-like, DEXD box c2 type; SPTR: Helicase c2. | KEGG: aco:Amico_1052 DNA polymerase III gamma/tau subunits-like protein; SPTR: DNA polymerase III gamma/tau subunits-like protein. | 0.895 |
Tlie_0706 | Tlie_1197 | Tlie_0706 | Tlie_1197 | PFAM: DEAD/DEAH box helicase; COGs: COG1199 Rad3-related DNA helicase; InterProIPR014013: IPR001650: IPR011545: IPR014001: IPR 006554: IPR006555; KEGG: aco:Amico_0691 helicase C2; PFAM: DEAD/DEAH box helicase domain protein; SMART: helicase c2; DEAD-like helicase; Helicase-like, DEXD box c2 type; SPTR: Helicase c2. | DNA polymerase I; PFAM: 5'-3' exonuclease, C-terminal SAM fold; DNA polymerase family A; 5'-3' exonuclease, N-terminal resolvase-like domain; TIGRFAM: DNA polymerase I; COGs: COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains; InterProIPR019760: IPR002421: IPR008918: IPR001098: IPR 002298: IPR018320: IPR020046: IPR020047; KEGG: aco:Amico_1259 DNA polymerase I; PFAM: DNA-directed DNA polymerase; 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; PRIAM: DNA-directed DNA polymerase; SMART: 5'-3' exonuclease; Helix-hairpin-helix domain [...] | 0.984 |
Tlie_0706 | acpP | Tlie_0706 | Tlie_1100 | PFAM: DEAD/DEAH box helicase; COGs: COG1199 Rad3-related DNA helicase; InterProIPR014013: IPR001650: IPR011545: IPR014001: IPR 006554: IPR006555; KEGG: aco:Amico_0691 helicase C2; PFAM: DEAD/DEAH box helicase domain protein; SMART: helicase c2; DEAD-like helicase; Helicase-like, DEXD box c2 type; SPTR: Helicase c2. | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | 0.804 |
Tlie_0706 | recA | Tlie_0706 | Tlie_0853 | PFAM: DEAD/DEAH box helicase; COGs: COG1199 Rad3-related DNA helicase; InterProIPR014013: IPR001650: IPR011545: IPR014001: IPR 006554: IPR006555; KEGG: aco:Amico_0691 helicase C2; PFAM: DEAD/DEAH box helicase domain protein; SMART: helicase c2; DEAD-like helicase; Helicase-like, DEXD box c2 type; SPTR: Helicase c2. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.895 |
Tlie_0706 | sbcD | Tlie_0706 | Tlie_0467 | PFAM: DEAD/DEAH box helicase; COGs: COG1199 Rad3-related DNA helicase; InterProIPR014013: IPR001650: IPR011545: IPR014001: IPR 006554: IPR006555; KEGG: aco:Amico_0691 helicase C2; PFAM: DEAD/DEAH box helicase domain protein; SMART: helicase c2; DEAD-like helicase; Helicase-like, DEXD box c2 type; SPTR: Helicase c2. | Exodeoxyribonuclease I subunit D; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. | 0.979 |
Tlie_0706 | topA | Tlie_0706 | Tlie_0531 | PFAM: DEAD/DEAH box helicase; COGs: COG1199 Rad3-related DNA helicase; InterProIPR014013: IPR001650: IPR011545: IPR014001: IPR 006554: IPR006555; KEGG: aco:Amico_0691 helicase C2; PFAM: DEAD/DEAH box helicase domain protein; SMART: helicase c2; DEAD-like helicase; Helicase-like, DEXD box c2 type; SPTR: Helicase c2. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.917 |
Tlie_0804 | Tlie_1197 | Tlie_0804 | Tlie_1197 | PFAM: Metallo-beta-lactamase superfamily; RNA-metabolising metallo-beta-lactamase; Beta-Casp domain; COGs: COG1236 exonuclease of the beta-lactamase fold involved in RNA processing; InterPro IPR011108; KEGG: aco:Amico_0410 beta-lactamase domain protein; PFAM: RNA-metabolising metallo-beta-lactamase; SPTR: Beta-lactamase domain protein; manually curated. | DNA polymerase I; PFAM: 5'-3' exonuclease, C-terminal SAM fold; DNA polymerase family A; 5'-3' exonuclease, N-terminal resolvase-like domain; TIGRFAM: DNA polymerase I; COGs: COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains; InterProIPR019760: IPR002421: IPR008918: IPR001098: IPR 002298: IPR018320: IPR020046: IPR020047; KEGG: aco:Amico_1259 DNA polymerase I; PFAM: DNA-directed DNA polymerase; 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; PRIAM: DNA-directed DNA polymerase; SMART: 5'-3' exonuclease; Helix-hairpin-helix domain [...] | 0.923 |
Tlie_0804 | sbcD | Tlie_0804 | Tlie_0467 | PFAM: Metallo-beta-lactamase superfamily; RNA-metabolising metallo-beta-lactamase; Beta-Casp domain; COGs: COG1236 exonuclease of the beta-lactamase fold involved in RNA processing; InterPro IPR011108; KEGG: aco:Amico_0410 beta-lactamase domain protein; PFAM: RNA-metabolising metallo-beta-lactamase; SPTR: Beta-lactamase domain protein; manually curated. | Exodeoxyribonuclease I subunit D; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. | 0.896 |
Tlie_1082 | Tlie_0002 | Tlie_1082 | Tlie_0002 | KEGG: aco:Amico_1052 DNA polymerase III gamma/tau subunits-like protein; SPTR: DNA polymerase III gamma/tau subunits-like protein. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.998 |
Tlie_1082 | Tlie_0706 | Tlie_1082 | Tlie_0706 | KEGG: aco:Amico_1052 DNA polymerase III gamma/tau subunits-like protein; SPTR: DNA polymerase III gamma/tau subunits-like protein. | PFAM: DEAD/DEAH box helicase; COGs: COG1199 Rad3-related DNA helicase; InterProIPR014013: IPR001650: IPR011545: IPR014001: IPR 006554: IPR006555; KEGG: aco:Amico_0691 helicase C2; PFAM: DEAD/DEAH box helicase domain protein; SMART: helicase c2; DEAD-like helicase; Helicase-like, DEXD box c2 type; SPTR: Helicase c2. | 0.895 |
Tlie_1082 | Tlie_1197 | Tlie_1082 | Tlie_1197 | KEGG: aco:Amico_1052 DNA polymerase III gamma/tau subunits-like protein; SPTR: DNA polymerase III gamma/tau subunits-like protein. | DNA polymerase I; PFAM: 5'-3' exonuclease, C-terminal SAM fold; DNA polymerase family A; 5'-3' exonuclease, N-terminal resolvase-like domain; TIGRFAM: DNA polymerase I; COGs: COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains; InterProIPR019760: IPR002421: IPR008918: IPR001098: IPR 002298: IPR018320: IPR020046: IPR020047; KEGG: aco:Amico_1259 DNA polymerase I; PFAM: DNA-directed DNA polymerase; 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; PRIAM: DNA-directed DNA polymerase; SMART: 5'-3' exonuclease; Helix-hairpin-helix domain [...] | 0.971 |
Tlie_1082 | recA | Tlie_1082 | Tlie_0853 | KEGG: aco:Amico_1052 DNA polymerase III gamma/tau subunits-like protein; SPTR: DNA polymerase III gamma/tau subunits-like protein. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.880 |
Tlie_1082 | sbcD | Tlie_1082 | Tlie_0467 | KEGG: aco:Amico_1052 DNA polymerase III gamma/tau subunits-like protein; SPTR: DNA polymerase III gamma/tau subunits-like protein. | Exodeoxyribonuclease I subunit D; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. | 0.901 |