STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
minCSeptum site-determining protein MinC; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization; Belongs to the MinC family. (216 aa)    
Predicted Functional Partners:
Tlie_0625
PFAM: CobQ/CobB/MinD/ParA nucleotide binding domain; TIGRFAM: septum site-determining protein MinD; COGs: COG2894 Septum formation inhibitor-activating ATPase; InterPro IPR010223; KEGG: aco:Amico_0606 septum site-determining protein MinD; SPTR: Septum site-determining protein MinD; TIGRFAM: septum site-determining protein MinD.
 
 
 0.998
Tlie_0621
PFAM: rod shape-determining protein MreC; TIGRFAM: rod shape-determining protein MreC; COGs: COG1792 Cell shape-determining protein; InterPro IPR007221; KEGG: aco:Amico_0602 rod shape-determining protein MreC; PFAM: Rod shape-determining protein MreC; SPTR: Rod shape-determining protein MreC.
  
  
 0.939
minE
Cell division topological specificity factor MinE; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
 
  
 0.921
ftsZ
Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
   
 
 0.909
Tlie_0620
PFAM: MreB/Mbl protein; TIGRFAM: cell shape determining protein, MreB/Mrl family; COGs: COG1077 Actin-like ATPase involved in cell morphogenesis; InterPro IPR004753: IPR004000; KEGG: aco:Amico_0601 cell shape determining protein, MreB/Mrl family; PFAM: cell shape determining protein MreB/Mrl; SMART: actin/actin family protein; SPTR: Cell shape determining protein, MreB/Mrl family; TIGRFAM: cell shape determining protein, MreB/Mrl family.
  
  
 0.732
tgt
tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...]
  
    0.717
Tlie_0623
Penicillin-binding protein 2; PFAM: Penicillin binding protein transpeptidase domain; Penicillin-binding Protein dimerisation domain; TIGRFAM: penicillin-binding protein 2; COGs: COG0768 Cell division protein FtsI/penicillin-binding protein 2; InterPro IPR005311: IPR001460: IPR017790; KEGG: tai:Taci_1207 penicillin-binding protein 2; PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain; PRIAM: Peptidoglycan glycosyltransferase; SPTR: Penicillin-binding protein 2; TIGRFAM: penicillin-binding protein 2.
  
  
 0.701
ffh
Signal recognition particle subunit FFH/SRP54 (srp54); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily.
  
  
 0.668
Tlie_0627
PFAM: Cell cycle protein; TIGRFAM: rod shape-determining protein RodA; COGs: COG0772 Bacterial cell division membrane protein; InterPro IPR001182: IPR011923; KEGG: aco:Amico_0608 rod shape-determining protein RodA; PFAM: cell cycle protein; SPTR: Rod shape-determining protein RodA; TIGRFAM: rod shape-determining protein RodA; Belongs to the SEDS family.
     
 0.660
Tlie_0622
PFAM: rod shape-determining protein MreD; KEGG: aco:Amico_0603 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.652
Your Current Organism:
Thermovirga lienii
NCBI taxonomy Id: 580340
Other names: T. lienii DSM 17291, Thermovirga lienii DSM 17291, Thermovirga lienii str. DSM 17291, Thermovirga lienii strain DSM 17291
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